Serial diffusion-weighted MRI and SPECT findings in a Creutzfeldt–Jakob disease patient with V180I mutation

We report serial changes of diffusion-weighted imaging (DWI) and single photon emission computed tomography (SPECT) in a patient with Creutzfeldt–Jakob disease with V180I mutation (CJD180). DWI abnormalities in our patient were more predominantly observed in the left cerebral cortex than left basal...

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Vydáno v:	Journal of the neurological sciences Ročník 301; číslo 1; s. 100 - 103
Hlavní autoři:	Kono, Syoichiro, Manabe, Yasuhiro, Fujii, Daiki, Sakai, Yasuko, Narai, Hisashi, Omori, Nobuhiko, Kitamoto, Tetsuyuki, Abe, Koji
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier B.V 15.02.2011 Elsevier
Témata:	Age of Onset Aged Akinetic Mutism - diagnostic imaging Akinetic Mutism - etiology Akinetic Mutism - pathology Biological and medical sciences Brain - diagnostic imaging Brain - pathology Creutzfeldt-Jakob Syndrome - complications Creutzfeldt-Jakob Syndrome - diagnostic imaging Creutzfeldt-Jakob Syndrome - epidemiology Creutzfeldt-Jakob Syndrome - genetics Creutzfeldt-Jakob Syndrome - pathology Creutzfeldt–Jakob disease Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diffusion Magnetic Resonance Imaging Disease Progression Early Diagnosis Follow-Up Studies Humans Magnetic resonance imaging Male Medical sciences Mutant Proteins - genetics Mutation, Missense Neurology Point Mutation Prion protein PrPSc Proteins - genetics SPECT Tomography, Emission-Computed, Single-Photon Magnetic resonance imaging Prion protein Creutzfeldt–Jakob disease SPECT Human Prion disease Nervous system diseases Creutzfeldt-Jakob disease Single photon emission tomography Nuclear magnetic resonance imaging Photon Cerebral disorder Infection Central nervous system disease Degenerative disease Prion Mutation Diffusion
ISSN:	0022-510X, 1878-5883, 1878-5883
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Popis
Shrnutí:	We report serial changes of diffusion-weighted imaging (DWI) and single photon emission computed tomography (SPECT) in a patient with Creutzfeldt–Jakob disease with V180I mutation (CJD180). DWI abnormalities in our patient were more predominantly observed in the left cerebral cortex than left basal ganglia. Hemilateral abnormalities progressed over 5 months to involve the contralateral side with increasing DWI signals. At 6 months, SPECT showed hypoperfusion in the left parietal and frontal lobes and the hypoperfusion region spread to the bilateral basal ganglia, right parietal and frontal lobes. SPECT imaging revealed marked cerebral blood flow reduction, predominantly in the cerebral cortex corresponding to brain areas with high-intensity DWI signals. During the follow-up period of CJD180, DWI was more sensitive than conventional FLAIR and T2-weighted images (T2WI) to detect and monitor the progression of abnormal hyperintense lesions. We suggest that serial DWI and SPECT findings are useful for not only early diagnosis of CJD but also for monitoring disease progression.
Bibliografie:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0022-510X 1878-5883 1878-5883
DOI:	10.1016/j.jns.2010.10.032