Porphyromonas gingivalis as a potential community activist for disease

An extensive analysis of dental plaque samples over the years has led to the identification of "red" complex oral bacteria that have a strong association with each other and with disease. Consequently, these bacteria have been labeled 'periopathogens'. Studies with one of these b...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of dental research Jg. 91; H. 9; S. 816
Hauptverfasser: Darveau, R P, Hajishengallis, G, Curtis, M A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.09.2012
Schlagworte:
Alveolar Bone Loss - microbiology
Animals
Bacterial Load
Chronic Periodontitis - immunology
Chronic Periodontitis - microbiology
Complement Activation
Dental Plaque - microbiology
Disease Models, Animal
Host-Pathogen Interactions
Humans
Mice
Microbial Consortia - physiology
Porphyromonas gingivalis - physiology
Specific Pathogen-Free Organisms
ISSN:1544-0591, 1544-0591
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An extensive analysis of dental plaque samples over the years has led to the identification of "red" complex oral bacteria that have a strong association with each other and with disease. Consequently, these bacteria have been labeled 'periopathogens'. Studies with one of these bacteria, Porphyromonas gingivalis, have revealed that it contains several different mechanisms which either impede or modulate periodontal protective mechanisms. In a mouse model of periodontitis, it has been shown that modulation of complement function by P. gingivalis facilitates a significant change in both the amount and composition of the normal oral microbiotia. This altered oral commensal microbiota is responsible for pathologic bone loss in the mouse. Thus, P. gingivalis creates a dysbiosis between the host and dental plaque, and this may represent one mechanism by which periodontitis can be initiated. We have therefore termed P. gingivalis a keystone pathogen.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1544-0591
1544-0591
DOI:10.1177/0022034512453589