Dynamic EMT: a multi‐tool for tumor progression

The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile. In cancer, this program is hijacked to confer essential changes in morphology and mot...

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Veröffentlicht in:	The EMBO journal Jg. 40; H. 18; S. e108647 - n/a
Hauptverfasser:	Brabletz, Simone, Schuhwerk, Harald, Brabletz, Thomas, Stemmler, Marc P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 15.09.2021 Springer Nature B.V John Wiley and Sons Inc
Schriftenreihe:	“Cancer Reviews 2021” series
Schlagworte:	Animals Biomarkers Cancer cell plasticity Cell Transformation, Neoplastic Disease Progression EMBO03 EMBO05 EMBO09 EMT Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Humans hybrid EMT invasion Mesenchyme MET metastasis Microenvironments Morphogenesis Morphology Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology partial EMT Review Reviews Signal Transduction signaling pathways SLUG SNAIL Therapeutic targets Tumor Microenvironment - genetics tumor stemness Tumorigenicity Tumors TWIST ZEB1 ZEB2 tumor stemness EMT SLUG hybrid EMT TWIST ZEB2 ZEB1 signaling pathways invasion partial EMT metastasis cancer cell plasticity MET SNAIL
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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