Dynamic EMT: a multi‐tool for tumor progression

The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile. In cancer, this program is hijacked to confer essential changes in morphology and mot...

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Vydané v:	The EMBO journal Ročník 40; číslo 18; s. e108647 - n/a
Hlavní autori:	Brabletz, Simone, Schuhwerk, Harald, Brabletz, Thomas, Stemmler, Marc P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 15.09.2021 Springer Nature B.V John Wiley and Sons Inc
Edícia:	“Cancer Reviews 2021” series
Predmet:	Animals Biomarkers Cancer cell plasticity Cell Transformation, Neoplastic Disease Progression EMBO03 EMBO05 EMBO09 EMT Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Humans hybrid EMT invasion Mesenchyme MET metastasis Microenvironments Morphogenesis Morphology Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology partial EMT Review Reviews Signal Transduction signaling pathways SLUG SNAIL Therapeutic targets Tumor Microenvironment - genetics tumor stemness Tumorigenicity Tumors TWIST ZEB1 ZEB2 tumor stemness EMT SLUG hybrid EMT TWIST ZEB2 ZEB1 signaling pathways invasion partial EMT metastasis cancer cell plasticity MET SNAIL
ISSN:	0261-4189, 1460-2075, 1460-2075
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Popis
Shrnutí:	The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile. In cancer, this program is hijacked to confer essential changes in morphology and motility that fuel invasion. In addition, EMT is increasingly understood to orchestrate a large variety of complementary cancer features, such as tumor cell stemness, tumorigenicity, resistance to therapy and adaptation to changes in the microenvironment. In this review, we summarize recent findings related to these various classical and non‐classical functions, and introduce EMT as a true tumorigenic multi‐tool, involved in many aspects of cancer. We suggest that therapeutic targeting of the EMT process will—if acknowledging these complexities—be a possibility to concurrently interfere with tumor progression on many levels. Graphical Abstract This review contrasts classical and non‐classical roles of epithelial‐mesenchymal transition in diverse aspects of cancer cell biology.
Bibliografia:	This article is part of the Cancer Reviews 2021 series . ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 This article is part of the Cancer Reviews 2021 series.
ISSN:	0261-4189 1460-2075 1460-2075
DOI:	10.15252/embj.2021108647