Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by...

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Veröffentlicht in:	BioEssays Jg. 42; H. 8; S. e2000014 - n/a
Hauptverfasser:	Fang, Liang‐Xing, Chen, Chong, Cui, Chao‐Yue, Li, Xing‐Ping, Zhang, Yan, Liao, Xiao‐Ping, Sun, Jian, Liu, Ya‐Hong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cambridge Wiley Subscription Services, Inc 01.08.2020
Schlagworte:	Antibiotic resistance Antibiotics Bacteria Epidemiology Gram-negative bacteria high‐level tigecycline resistance humans molecular epidemiology pan‐drug‐resistant plasmid reservoirs plasmid‐encoding tigecycline enzymatic inactivation Public health Tet(X) tetracycline tetracycline antibiotics tetracycline destructases Tetracyclines Tigecycline Veterinary medicine
ISSN:	0265-9247, 1521-1878, 1521-1878
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Abstract	Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine. The novel mobile tetracycline‐inactivating enzymes, Tet(X3)–Tet(X5), could confer high‐level tigecycline resistance. They have been disseminated in diverse bacterial hosts from a wide range of ecological niches through promiscuous plasmids and ISCR2. This complex dissemination can be driven by selective pressure from the massive use of the early tetracyclines.
AbstractList	Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine. The novel mobile tetracycline‐inactivating enzymes, Tet(X3)–Tet(X5), could confer high‐level tigecycline resistance. They have been disseminated in diverse bacterial hosts from a wide range of ecological niches through promiscuous plasmids and ISCR2. This complex dissemination can be driven by selective pressure from the massive use of the early tetracyclines. Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine. Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by pan-drug-resistant bacterial pathogens. Unfortunately, this last-resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high-level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next-generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large-scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram-negative bacteria in both human and veterinary medicine.Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by pan-drug-resistant bacterial pathogens. Unfortunately, this last-resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high-level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next-generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large-scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram-negative bacteria in both human and veterinary medicine.
Author	Fang, Liang‐Xing Chen, Chong Cui, Chao‐Yue Liu, Ya‐Hong Liao, Xiao‐Ping Zhang, Yan Li, Xing‐Ping Sun, Jian
Author_xml	– sequence: 1 givenname: Liang‐Xing surname: Fang fullname: Fang, Liang‐Xing organization: South China Agricultural University – sequence: 2 givenname: Chong surname: Chen fullname: Chen, Chong organization: South China Agricultural University – sequence: 3 givenname: Chao‐Yue surname: Cui fullname: Cui, Chao‐Yue organization: South China Agricultural University – sequence: 4 givenname: Xing‐Ping surname: Li fullname: Li, Xing‐Ping organization: South China Agricultural University – sequence: 5 givenname: Yan surname: Zhang fullname: Zhang, Yan organization: South China Agricultural University – sequence: 6 givenname: Xiao‐Ping surname: Liao fullname: Liao, Xiao‐Ping organization: South China Agricultural University – sequence: 7 givenname: Jian surname: Sun fullname: Sun, Jian email: jiansun@scau.edu.cn organization: South China Agricultural University – sequence: 8 givenname: Ya‐Hong orcidid: 0000-0002-4583-8291 surname: Liu fullname: Liu, Ya‐Hong email: lyh@scau.edu.cn organization: South China Agricultural University
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Snippet	Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of... Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of...
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SubjectTerms	Antibiotic resistance Antibiotics Bacteria Epidemiology Gram-negative bacteria high‐level tigecycline resistance humans molecular epidemiology pan‐drug‐resistant plasmid reservoirs plasmid‐encoding tigecycline enzymatic inactivation Public health Tet(X) tetracycline tetracycline antibiotics tetracycline destructases Tetracyclines Tigecycline Veterinary medicine
Title	Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)
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