Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model

Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling crucial in AD development. A defective variant, ubiquitin B + 1 (UBB +1 ), created by a non-hereditary RNA frameshift m...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 5922 - 14
Main Authors:	Maniv, Inbal, Sarji, Mahasen, Bdarneh, Anwar, Feldman, Alona, Ankawa, Roi, Koren, Elle, Magid-Gold, Inbar, Reis, Noa, Soteriou, Despina, Salomon-Zimri, Shiran, Lavy, Tali, Kesselman, Ellina, Koifman, Naama, Kurz, Thimo, Kleifeld, Oded, Michaelson, Daniel, van Leeuwen, Fred W., Verheijen, Bert M., Fuchs, Yaron, Glickman, Michael H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/89 14/1 14/35 14/63 631/378/2611 631/45/474/582 631/80/304 82/16 82/29 82/80 Alzheimer's disease Amyloid precursor protein Cell culture Frameshift mutation Humanities and Social Sciences multidisciplinary Mutation Neural stem cells Neurodegenerative diseases Neurons Pathology Peptides Protein gene product 9.5 Proteins Science Science (multidisciplinary) Tau protein Ubiquitin Ubiquitination β-Amyloid
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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