Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model

Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling crucial in AD development. A defective variant, ubiquitin B + 1 (UBB +1 ), created by a non-hereditary RNA frameshift m...

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Vydáno v:	Nature communications Ročník 14; číslo 1; s. 5922 - 14
Hlavní autoři:	Maniv, Inbal, Sarji, Mahasen, Bdarneh, Anwar, Feldman, Alona, Ankawa, Roi, Koren, Elle, Magid-Gold, Inbar, Reis, Noa, Soteriou, Despina, Salomon-Zimri, Shiran, Lavy, Tali, Kesselman, Ellina, Koifman, Naama, Kurz, Thimo, Kleifeld, Oded, Michaelson, Daniel, van Leeuwen, Fred W., Verheijen, Bert M., Fuchs, Yaron, Glickman, Michael H.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 22.09.2023 Nature Publishing Group Nature Portfolio
Témata:	13/1 13/106 13/109 13/89 14/1 14/35 14/63 631/378/2611 631/45/474/582 631/80/304 82/16 82/29 82/80 Alzheimer's disease Amyloid precursor protein Cell culture Frameshift mutation Humanities and Social Sciences multidisciplinary Mutation Neural stem cells Neurodegenerative diseases Neurons Pathology Peptides Protein gene product 9.5 Proteins Science Science (multidisciplinary) Tau protein Ubiquitin Ubiquitination β-Amyloid
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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