Genetic contributions to brain serotonin transporter levels in healthy adults

The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by regulating extracellular brain serotonin levels; it remains unclear to what extent 5-HTT levels in the human brain are genetically determined. Here we applied [ 11 C]DASB positron emission tomography to image brain 5-...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 16426 - 11
Main Authors:	Bruzzone, Silvia Elisabetta Portis, Nasser, Arafat, Aripaka, Sagar Sanjay, Spies, Marie, Ozenne, Brice, Jensen, Peter Steen, Knudsen, Gitte Moos, Frokjaer, Vibe Gedsoe, Fisher, Patrick MacDonald
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/378/2583 631/378/2587 631/378/548/1964 Amygdala Brain Brain-derived neurotrophic factor Genetic diversity Genetic variance Genotypes Homozygotes Humanities and Social Sciences Mesencephalon multidisciplinary Neocortex Neuroimaging Neurotransmission Positron emission tomography Prediction models Putamen Science Science (multidisciplinary) Serotonin Serotonin transporter Statistical analysis Thalamus
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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