Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion

Overcoming antimicrobial resistance represents a formidable challenge and investigating bacterial growth inhibition by fungal metabolites may yield new strategies. Although the fungal non-ribosomal peptide gliotoxin (GT) is known to exhibit antibacterial activity, the mechanism(s) of action are unkn...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 16156 - 20
Main Authors:	Downes, Shane G., Owens, Rebecca A., Walshe, Kieran, Fitzpatrick, David A., Dorey, Amber, Jones, Gary W., Doyle, Sean
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/326 631/326/22 631/326/252 631/326/2522 631/326/41 631/92 631/92/475 Antibacterial activity Antibiotics Antimicrobial resistance Bacteria Bioavailability Chelates Chelation Copper Dithiothreitol Gliotoxin Homeostasis Humanities and Social Sciences Inhibition Intracellular Ions Iron Mass spectrometry Mass spectroscopy Metabolites Metal ions multidisciplinary Proteomes Proteomics Reagents Resorcinol Science Science (multidisciplinary) Vancomycin Zinc
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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