Non-transferrin bound iron: A key role in iron overload and iron toxicity

Besides transferrin iron, which represents the normal form of circulating iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients with various pathological conditions in which transferrin saturation is significantly elevated. To show that: i) NTBI is present not only du...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1820; no. 3; pp. 403 - 410
Main Authors:	Brissot, Pierre, Ropert, Martine, Le Lan, Caroline, Loréal, Olivier
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.03.2012
Subjects:	Cell Death ferritin Ferritins - blood Ferroportin Hemochromatosis Hemochromatosis - blood Hepcidin Humans Ion Transport iron Iron - blood Iron - metabolism Iron overload Iron Overload - blood Liver - metabolism Non-transferrin bound iron (NTBI) organelles patients plasma membrane reactive oxygen species Reactive Oxygen Species - metabolism Thalassemia toxicity transferrin Transferrin - metabolism Ferroportin Iron overload Thalassemia Hemochromatosis Hepcidin Non-transferrin bound iron (NTBI)
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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