Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1

Cisplatin (DDP) is a key chemotherapeutic agent in the treatment of gastric cancer; however, its efficacy is often limited by chemoresistance, a notable challenge in clinical oncology. The present study aimed to investigate the influence of exosomes derived from M2-polarized macrophages, which promo...

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Veröffentlicht in:	Molecular medicine reports Jg. 31; H. 4
Hauptverfasser:	Wei, Wujun, Li, Jiaxing, Huang, Jingjing, Jiang, Qi, Lin, Cheng, Hu, Rentong, Wei, Jiazhu, Li, Qiao, Xu, Guidan, Chang, Zhengyi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Greece D.A. Spandidos 01.04.2025 Spandidos Publications Spandidos Publications UK Ltd
Schlagworte:	Animals Antibodies Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biotechnology Calnexin Cancer cells Cancer therapies Care and treatment CD163 antigen CD9 antigen Cell differentiation Cell growth Cell Line, Tumor Chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology cisplatin resistance Cytokines Dosage and administration Drug resistance Drug Resistance, Neoplasm - genetics Exosomes Exosomes - genetics Exosomes - metabolism Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Humans Immunofluorescence Immunotherapy Invoices M2 macrophages Macrophages Macrophages - drug effects Macrophages - metabolism Mice microRNA-3681-3p MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Microscopy miRNA MLH1 MLH1 protein MutL protein MutL Protein Homolog 1 - genetics MutL Protein Homolog 1 - metabolism Physiological aspects RNA-mediated interference siRNA Stomach cancer Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Therapeutic targets Transfection Transmission electron microscopy Tumor necrosis factor-TNF China M2 macrophages gastric cancer MLH1 microRNA‑3681‑3p cisplatin resistance
ISSN:	1791-2997, 1791-3004, 1791-3004
Online-Zugang:	Volltext
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