Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes

Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified only a small number of loci associated with sex hormone levels, with several reproductive hormones yet to be assessed. The...

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Vydáno v:	European journal of human genetics : EJHG Ročník 24; číslo 2; s. 284 - 290
Hlavní autoři:	Ruth, Katherine S, Campbell, Purdey J, Chew, Shelby, Lim, Ee Mun, Hadlow, Narelle, Stuckey, Bronwyn GA, Brown, Suzanne J, Feenstra, Bjarke, Joseph, John, Surdulescu, Gabriela L, Zheng, Hou Feng, Richards, J Brent, Murray, Anna, Spector, Tim D, Wilson, Scott G, Perry, John RB
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.02.2016
Témata:	Chromosome 7 Dehydroepiandrosterone Dehydroepiandrosterone Sulfate - metabolism Diabetes Epidemiology Estradiol - genetics Female Follicle Stimulating Hormone - genetics Follicle Stimulating Hormone - metabolism Follicle-stimulating hormone Gene expression Gene frequency Genetic factors Genetic variance Genetics Genome, Human Genome-Wide Association Study Genomes Genotype Genotypes Globulins Gonadal Steroid Hormones - genetics Gonadal Steroid Hormones - metabolism Hospitals Humans Kinases Licenses Luteinizing hormone Luteinizing Hormone - genetics Luteinizing Hormone - metabolism Male Males Menstrual cycle Menstruation Metabolism Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Progesterone Progesterone - genetics Prolactin Prolactin - genetics Prolactin - metabolism Sex Sex Hormone-Binding Globulin - genetics Sex Hormone-Binding Globulin - metabolism Sex hormones Single-nucleotide polymorphism Studies Testosterone Testosterone - genetics Canada Montreal Quebec Canada United Kingdom > UK Australia
ISSN:	1018-4813, 1476-5438, 1476-5438
On-line přístup:	Získat plný text
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