Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection

Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a po...

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Bibliographic Details
Published in:	Cell death & disease Vol. 14; no. 11; pp. 727 - 11
Main Authors:	Rosli, Sarah, Harpur, Christopher M., Lam, Maggie, West, Alison C., Hodges, Christopher, Mansell, Ashley, Lawlor, Kate E., Tate, Michelle D.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.11.2023 Springer Nature B.V Nature Publishing Group
Subjects:	13/21 13/31 13/51 14 14/19 631/250/254 631/250/256/2177 64 82/80 96/106 Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell death Chemokines Disease resistance Epithelial cells Immunology Infections Inflammation Influenza Influenza A Interleukins Leukocytes (neutrophilic) Life Sciences Lung diseases Monocyte chemoattractant protein 1 Neutrophils Pyroptosis
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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