Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that basal levels of the IFN-stimulated gene 15, ISG15, and its c...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6140 - 15
Main Authors:	Moro, Ramona N., Biswas, Uddipta, Kharat, Suhas S., Duzanic, Filip D., Das, Prosun, Stavrou, Maria, Raso, Maria C., Freire, Raimundo, Chaudhuri, Arnab Ray, Sharan, Shyam K., Penengo, Lorenza
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.10.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/337/151/2356 631/67/1059/2326 631/80/304 631/80/458/582 631/80/86 82/29 82/47 82/58 96/63 96/95 BRCA1 protein BRCA2 protein Breast cancer Cell proliferation Cell viability Chemotherapy Cisplatin Conjugation Defects Deoxyribonucleic acid DNA DNA biosynthesis DNA repair Drug resistance Embryo cells Genotoxicity Humanities and Social Sciences Inactivation Inflammation Interferon Lethality multidisciplinary Replication Science Science (multidisciplinary) Stability Stem cells Up-regulation β-Interferon
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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