The TIGIT+ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation

The TIGIT + FOXP3 + Treg subset (TIGIT + Tregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic infection. We hypothesized that TIGIT + Tregs could play an important role in intensifying the COVID-19 severity and hampering the defense again...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 13599 - 12
Main Authors:	de Lima, Mikhael Haruo Fernandes, Machado, Caio Cavalcante, Nascimento, Daniele Carvalho, Silva, Camila Meirelles S., Toller-Kawahisa, Juliana Escher, Rodrigues, Tamara Silva, Veras, Flavio Protassio, Pontelli, Marjorie Cornejo, Castro, Italo A., Zamboni, Dario Simões, Filho, José-Carlos A., Cunha, Thiago M., Arruda, Eurico, da Cunha, Larissa Dias, Oliveira, Renê D. R., Cunha, Fernando Q., Louzada-Junior, Paulo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.08.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/250 631/250/1619 631/250/1619/554 631/250/2152 631/250/255 631/250/256 Bacteremia Cell-mediated immunity COVID-19 Flow cytometry Foxp3 protein HMGB1 protein Hospitalization Hospitals Humanities and Social Sciences Immunoregulation Interleukin 10 Interleukin 6 Lymphocytes T Mechanical ventilation multidisciplinary Nosocomial infection Nosocomial infections Opportunist infection Peripheral blood Plasma levels Respiratory function Science Science (multidisciplinary) Ventilation
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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