The TIGIT+ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation

The TIGIT + FOXP3 + Treg subset (TIGIT + Tregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic infection. We hypothesized that TIGIT + Tregs could play an important role in intensifying the COVID-19 severity and hampering the defense again...

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Published in:Scientific reports Vol. 13; no. 1; pp. 13599 - 12
Main Authors: de Lima, Mikhael Haruo Fernandes, Machado, Caio Cavalcante, Nascimento, Daniele Carvalho, Silva, Camila Meirelles S., Toller-Kawahisa, Juliana Escher, Rodrigues, Tamara Silva, Veras, Flavio Protassio, Pontelli, Marjorie Cornejo, Castro, Italo A., Zamboni, Dario Simões, Filho, José-Carlos A., Cunha, Thiago M., Arruda, Eurico, da Cunha, Larissa Dias, Oliveira, Renê D. R., Cunha, Fernando Q., Louzada-Junior, Paulo
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 21.08.2023
Nature Publishing Group
Nature Portfolio
Subjects:
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Bacteremia
Cell-mediated immunity
COVID-19
Flow cytometry
Foxp3 protein
HMGB1 protein
Hospitalization
Hospitals
Humanities and Social Sciences
Immunoregulation
Interleukin 10
Interleukin 6
Lymphocytes T
Mechanical ventilation
multidisciplinary
Nosocomial infection
Nosocomial infections
Opportunist infection
Peripheral blood
Plasma levels
Respiratory function
Science
Science (multidisciplinary)
Ventilation
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:The TIGIT + FOXP3 + Treg subset (TIGIT + Tregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic infection. We hypothesized that TIGIT + Tregs could play an important role in intensifying the COVID-19 severity and hampering the defense against nosocomial infections during hospitalization. Herein we aimed to verify the association between the levels of the TIGIT + Tregs with the mechanical ventilation requirement, fatal outcome, and bacteremia during hospitalization. TIGIT + Tregs were immunophenotyped by flow cytometry from the peripheral blood of 72 unvaccinated hospitalized COVID-19 patients at admission from May 29th to August 6th, 2020. The patients were stratified during hospitalization according to their mechanical ventilation requirement and fatal outcome. COVID-19 resulted in a high prevalence of the TIGIT + Tregs at admission, which progressively increased in patients with mechanical ventilation needs and fatal outcomes. The prevalence of TIGIT + Tregs positively correlated with poor pulmonary function and higher plasma levels of LDH, HMGB1, FGL2, and TNF. The non-survivors presented higher plasma levels of IL-33, HMGB1, FGL2, IL-10, IL-6, and 5.54 times more bacteremia than survivors. Conclusions: The expansion of the TIGIT + Tregs in COVID-19 patients was associated with inflammation, lung dysfunction, bacteremia, and fatal outcome.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-39924-7