Elevated Plasma Growth and Differentiation Factor 15 Predicts Incident Anemia in Older Adults Aged 60 Years and Older

Anemia is common in older adults and associated with greater morbidity and mortality. The causes of anemia in older adults have not been completely characterized. Although elevated circulating growth and differentiation factor 15 (GDF-15) has been associated with anemia in older adults, it is not kn...

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Vydáno v:The journals of gerontology. Series A, Biological sciences and medical sciences Ročník 76; číslo 7; s. 1192
Hlavní autoři: Yamaguchi, Yuko, Zampino, Marta, Tanaka, Toshiko, Bandinelli, Stefania, Osawa, Yusuke, Ferrucci, Luigi, Semba, Richard D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 14.06.2021
Témata:
Aged
Aged, 80 and over
Anemia - epidemiology
Biomarkers - metabolism
Comorbidity
Female
Growth Differentiation Factor 15 - metabolism
Humans
Incidence
Italy - epidemiology
Male
Middle Aged
Predictive Value of Tests
Risk Factors
Italy
Human aging
Senescence
Anemia
Proteomics
ISSN:1758-535X, 1758-535X
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Shrnutí:Anemia is common in older adults and associated with greater morbidity and mortality. The causes of anemia in older adults have not been completely characterized. Although elevated circulating growth and differentiation factor 15 (GDF-15) has been associated with anemia in older adults, it is not known whether elevated GDF-15 predicts the development of anemia. We examined the relationship between plasma GDF-15 concentrations at baseline in 708 nonanemic adults, aged 60 years and older, with incident anemia during 15 years of follow-up among participants in the Invecchiare in Chianti (InCHIANTI) Study. During follow-up, 179 (25.3%) participants developed anemia. The proportion of participants who developed anemia from the lowest to highest quartile of plasma GDF-15 was 12.9%, 20.1%, 21.2%, and 45.8%, respectively. Adults in the highest quartile of plasma GDF-15 had an increased the risk of developing anemia (hazards ratio 1.15, 95% confidence interval 1.09, 1.21, p < .0001) compared to those in the lower 3 quartiles in a multivariable Cox proportional hazards model adjusting for age, sex, serum iron, soluble transferrin receptor, ferritin, vitamin B12, congestive heart failure, diabetes mellitus, and cancer. Circulating GDF-15 is an independent predictor for the development of anemia in older adults.
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ISSN:1758-535X
1758-535X
DOI:10.1093/gerona/glaa324