FGFR2 genetic variants in women with breast cancer

Black African populations are more genetically diverse than others, but genetic variants have been studied primarily in European populations. The present study examined the association of four single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2, associated with breast c...

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Bibliographic Details
Published in:Molecular medicine reports Vol. 28; no. 6
Main Authors: Dix-Peek, Thérèse, Dickens, Caroline, Augustine, Tanya N, Phakathi, Boitumelo P, Van Den Berg, Eunice J, Joffe, Maureen, Ayeni, Oluwatosin A, Cubasch, Herbert, Nietz, Sarah, Mathew, Christopher G, Hayat, Mahtaab, Neugut, Alfred I, Jacobson, Judith S, Ruff, Paul, Duarte, Raquel A.B
Format: Journal Article
Language:English
Published: Greece D.A. Spandidos 01.12.2023
Spandidos Publications
Spandidos Publications UK Ltd
Subjects:
African
African Americans
Alleles
Analysis
Black People - genetics
Breast cancer
Breast Neoplasms - pathology
Case-Control Studies
Female
FGFR2
Fibroblast growth factor receptor 2
Fibroblast growth factor receptors
Genetic aspects
Genetic diversity
Genetic Predisposition to Disease
Genetic susceptibility
Genetic variation
Genomics
Genotype
Health aspects
heterogenous
Humans
Physiological aspects
Polymorphism, Single Nucleotide
Population genetics
Population studies
Receptor, Fibroblast Growth Factor, Type 2 - genetics
Receptor, Fibroblast Growth Factor, Type 2 - metabolism
risk
Risk factors
Single-nucleotide polymorphism
SNP
South Africa
Womens health
South Africa
breast cancer
risk
SNP
heterogenous
FGFR2
African
ISSN:1791-2997, 1791-3004, 1791-3004
Online Access:Get full text
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Summary:Black African populations are more genetically diverse than others, but genetic variants have been studied primarily in European populations. The present study examined the association of four single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2, associated with breast cancer in non-African populations, with breast cancer in Black, southern African women. Genomic DNA was extracted from whole blood samples of 1,001 patients with breast cancer and 1,006 controls (without breast cancer), and the rs2981582, rs35054928, rs2981578, and rs11200014 polymorphisms were analyzed using allele-specific Kompetitive allele-specific PCR™, and the χ2 or Fisher's exact tests were used to compare the genotype frequencies. There was no association between those SNPs and breast cancer in the studied cohort, although an association was identified between the C/C homozygote genotype for rs2981578 and invasive lobular carcinoma. These results show that genetic biomarkers of breast cancer risk in European populations are not necessarily associated with risk in sub-Saharan African populations. African populations are more heterogenous than other populations, and the information from this population can help focus genetic risks of cancer in this understudied population.
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ISSN:1791-2997
1791-3004
1791-3004
DOI:10.3892/mmr.2023.13113