Complement factor C5a induces atherosclerotic plaque disruptions

Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE−/− mice. After 24 days, when advanced p...

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Bibliographic Details
Published in:	Journal of cellular and molecular medicine Vol. 18; no. 10; pp. 2020 - 2030
Main Authors:	Wezel, Anouk, Vries, Margreet R., Lagraauw, H. Maxime, Foks, Amanda C., Kuiper, Johan, Quax, Paul H.A., Bot, Ilze
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.10.2014 BlackWell Publishing Ltd
Subjects:	Animals Apolipoprotein E Apolipoproteins E - physiology Apoptosis Arteriosclerosis Atherosclerosis C5a Cells, Cultured Complement C5a - genetics Complement C5a - metabolism Complement component C5a Endothelial cells Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Hemorrhage Immunoenzyme Techniques Laboratory animals Male Mice Mice, Knockout Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Original plaque rupture Plaque, Atherosclerotic - etiology Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaques R&D Real-Time Polymerase Chain Reaction Receptor, Anaphylatoxin C5a - genetics Receptor, Anaphylatoxin C5a - metabolism Research & development Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Smooth muscle Surgery Veins & arteries Belgium United States > US Netherlands atherosclerosis plaque rupture apoptosis C5a
ISSN:	1582-1838, 1582-4934, 1582-4934
Online Access:	Get full text
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