Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging

ABSTRACT Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized b...

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Vydané v:	Movement disorders Ročník 28; číslo 13; s. 1886 - 1890
Hlavní autori:	Rizzo, Giovanni, Manners, David, Testa, Claudia, Tonon, Caterina, Vetrugno, Roberto, Marconi, Sara, Plazzi, Giuseppe, Pizza, Fabio, Provini, Federica, Malucelli, Emil, Gramegna, Laura Ludovica, Lodi, Raffaele
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Blackwell Publishing Ltd 01.11.2013 Wiley Subscription Services, Inc
Predmet:	Aged Brain - metabolism Female Humans iron Iron - metabolism Magnetic Resonance Imaging Male Middle Aged Movement disorders MRI phase imaging Restless Legs Syndrome - pathology RLS Statistics, Nonparametric RLS iron MRI phase imaging
ISSN:	0885-3185, 1531-8257, 1531-8257
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Abstract	ABSTRACT Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate. Results Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients. Conclusions We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society
AbstractList	Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS patients and 15 healthy controls were studied using gradient-echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate. Results Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients. Conclusions We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society [PUBLICATION ABSTRACT] The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).BACKGROUNDThe objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).Fifteen RLS patients and 15 healthy controls were studied using gradient-echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate.METHODSFifteen RLS patients and 15 healthy controls were studied using gradient-echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate.Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients.RESULTSSignificantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients.We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder.CONCLUSIONSWe have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. ABSTRACT Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate. Results Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients. Conclusions We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Fifteen RLS patients and 15 healthy controls were studied using gradient-echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate. Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients. We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder.
Author	Testa, Claudia Vetrugno, Roberto Provini, Federica Gramegna, Laura Ludovica Marconi, Sara Pizza, Fabio Rizzo, Giovanni Lodi, Raffaele Manners, David Malucelli, Emil Plazzi, Giuseppe Tonon, Caterina
Author_xml	– sequence: 1 givenname: Giovanni surname: Rizzo fullname: Rizzo, Giovanni organization: Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 2 givenname: David surname: Manners fullname: Manners, David organization: Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 3 givenname: Claudia surname: Testa fullname: Testa, Claudia organization: Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 4 givenname: Caterina surname: Tonon fullname: Tonon, Caterina organization: Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 5 givenname: Roberto surname: Vetrugno fullname: Vetrugno, Roberto organization: Professional Consultant in Neurology, Bologna, Italy – sequence: 6 givenname: Sara surname: Marconi fullname: Marconi, Sara organization: Neurology Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 7 givenname: Giuseppe surname: Plazzi fullname: Plazzi, Giuseppe organization: Neurology Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 8 givenname: Fabio surname: Pizza fullname: Pizza, Fabio organization: Neurology Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 9 givenname: Federica surname: Provini fullname: Provini, Federica organization: Neurology Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 10 givenname: Emil surname: Malucelli fullname: Malucelli, Emil organization: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy – sequence: 11 givenname: Laura Ludovica surname: Gramegna fullname: Gramegna, Laura Ludovica organization: Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy – sequence: 12 givenname: Raffaele surname: Lodi fullname: Lodi, Raffaele email: raffaele.lodi@unibo.it organization: Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy
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Snippet	ABSTRACT Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome... The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Fifteen RLS... Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).... The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).BACKGROUNDThe...
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SubjectTerms	Aged Brain - metabolism Female Humans iron Iron - metabolism Magnetic Resonance Imaging Male Middle Aged Movement disorders MRI phase imaging Restless Legs Syndrome - pathology RLS Statistics, Nonparametric
Title	Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging
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