Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension

Enhanced proliferation, resistance to apoptosis, and metabolic shift to glycolysis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are key pathophysiological components of pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (PAH). The role of the distinct mammali...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 129; no. 8; p. 864
Main Authors:	Goncharov, Dmitry A, Kudryashova, Tatiana V, Ziai, Houman, Ihida-Stansbury, Kaori, DeLisser, Horace, Krymskaya, Vera P, Tuder, Rubin M, Kawut, Steven M, Goncharova, Elena A
Format:	Journal Article
Language:	English
Published:	United States 25.02.2014
Subjects:	Animals Carrier Proteins - metabolism Cell Proliferation Cell Survival - physiology Cells, Cultured Energy Metabolism - physiology Familial Primary Pulmonary Hypertension Female Glycolysis - physiology Humans Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypoxia - metabolism Hypoxia - pathology Male Mechanistic Target of Rapamycin Complex 2 Multiprotein Complexes - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Pulmonary Artery - cytology Pulmonary Artery - metabolism Rapamycin-Insensitive Companion of mTOR Protein Rats Rats, Sprague-Dawley Signal Transduction - physiology TOR Serine-Threonine Kinases - metabolism remodeling signal transduction muscle, smooth, vascular AMP-activated protein kinase mTORC2 energy metabolism idiopathic pulmonary arterial hypertension
ISSN:	1524-4539, 1524-4539
Online Access:	Get more information
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