The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells – the NLRP3 inflammasome – in atherosclerosis-associated inflammation...

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Veröffentlicht in:	Atherosclerosis Jg. 269; S. 262 - 271
Hauptverfasser:	Martínez, Gonzalo J., Celermajer, David S., Patel, Sanjay
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Ireland Elsevier B.V 01.02.2018
Schlagworte:	Acute coronary syndrome Animals Anti-Inflammatory Agents - therapeutic use Arteries - drug effects Arteries - metabolism Arteries - pathology Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Atherosclerosis - pathology Colchicine Colchicine - therapeutic use Cytokines - metabolism Humans Inflammasome Inflammasomes - antagonists & inhibitors Inflammasomes - metabolism Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Macrophages - drug effects Macrophages - metabolism Monocytes - drug effects Monocytes - metabolism Myocardial infarction Neutrophils - drug effects Neutrophils - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Plaque, Atherosclerotic Signal Transduction - drug effects Myocardial infarction Inflammation Inflammasome Colchicine Acute coronary syndrome Atherosclerosis
ISSN:	0021-9150, 1879-1484, 1879-1484
Online-Zugang:	Volltext
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