Apoptosis in Skeletal Myocytes: A Potential Target for Interventions against Sarcopenia and Physical Frailty – A Mini-Review
Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates tha...
Gespeichert in:
| Veröffentlicht in: | Gerontology (Basel) Jg. 58; H. 2; S. 99 - 106 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Basel, Switzerland
Karger
01.02.2012
S. Karger AG |
| Schlagworte: | |
| ISSN: | 0304-324X, 1423-0003, 1423-0003 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions. Objective: We aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging. Methods: We summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss. Results: Advanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1α overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated. Conclusions: Available evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening. |
|---|---|
| AbstractList | Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions. Objective: We aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging. Methods: We summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss. Results: Advanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1α overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated. Conclusions: Available evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening. Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions. Objective: We aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging. Methods: We summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss. Results: Advanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1α overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated. Conclusions: Available evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening.[PUBLICATION ABSTRACT] Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions.BACKGROUNDSarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions.We aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging.OBJECTIVEWe aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging.We summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss.METHODSWe summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss.Advanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1α overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated.RESULTSAdvanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1α overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated.Available evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening.CONCLUSIONSAvailable evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening. Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions. Objective: We aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging. Methods: We summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss. Results: Advanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1 alpha overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated. Conclusions: Available evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening. Copyright [copy 2011 S. Karger AG, Basel Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental consequences. While the exact mechanisms underlying the pathogenesis of sarcopenia are not clear, growing experimental evidence indicates that progressive myonuclear elimination over the course of aging via an apoptosis-like process may represent a converging mechanism through which muscle atrophy and loss of physical function develop. Notably, the proapoptotic environment taking place in aged muscle appears amenable to interventions. We aimed at providing (1) an overview of signaling pathways of apoptosis relevant to sarcopenia, and (2) a review of the literature supporting myocyte apoptosis as a target for interventions against muscle aging. We summarized findings from studies focused on skeletal myocyte apoptosis as a mechanism in the development of sarcopenia and reports supporting myonuclear apoptosis as a target for interventions against age-related muscle loss. Advanced age is associated with increased signaling through extrinsic and intrinsic apoptotic pathways in skeletal myocytes. In contrast, downregulation of myocyte apoptosis through calorie restriction, exercise training, hormonal supplementation, drugs (e.g. angiotensin-converting enzyme inhibitors, acetaminophen, antimyostatin antibodies), nutraceuticals or genetic interventions (e.g. PGC-1α overexpression) is linked with preservation of muscle integrity and improved physical performance in late life. Preliminary data also indicate that skeletal myocyte apoptotic signaling may be downregulated by compounds, such as resveratrol, with calorie restriction-mimicking properties. Whether exercise mimetics exert a similar effect has not yet been investigated. Available evidence suggests that targeting myonuclear apoptosis might provide novel and effective therapeutic tools to combat sarcopenia. Further research is required to definitely establish if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening. |
| Author | Calvani, Riccardo Leeuwenburgh, Christiaan Bernabei, Roberto Marzetti, Emanuele |
| AuthorAffiliation | c Department of Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, Fla., USA b Department of Gerontology, Geriatrics and Physiatrics, University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy a Department of Orthopaedics and Traumatology University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy |
| AuthorAffiliation_xml | – name: a Department of Orthopaedics and Traumatology University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy – name: b Department of Gerontology, Geriatrics and Physiatrics, University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy – name: c Department of Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, Fla., USA |
| Author_xml | – sequence: 1 givenname: Emanuele surname: Marzetti fullname: Marzetti, Emanuele email: emarzetti@live.com – sequence: 2 givenname: Riccardo surname: Calvani fullname: Calvani, Riccardo – sequence: 3 givenname: Roberto surname: Bernabei fullname: Bernabei, Roberto – sequence: 4 givenname: Christiaan surname: Leeuwenburgh fullname: Leeuwenburgh, Christiaan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26885737$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21952604$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kt9rFDEQx4NU7LX64LtIoIj6sHay2ewPH4SjWC20WOw9-LbksrPXtHvJmuRO9kX8H_wP_UvMcuepRYRA4Duf-WYyMwdkz1iDhDxm8IoxUR0DAOcAeXaPTFiW8mQU9sgEOGQJT7NP--TA-5soQsrgAdlPWSXSHLIJ-TrtbR-s155qQ69uscMgO3oxWDUE9K_plF7agCboqM6kW2CgrXX0zAR061G3xlO5kNr4QK-kU7ZHoyWVpqGX14PXKiaeOqm7MNAf375HwwttdPIR1xq_PCT3W9l5fLS9D8ns9O3s5H1y_uHd2cn0PFGCFSHBIm8wV5hjCWqOFTRtWs5zaMvxu5ADk1XDC8matCyLKMg5j41Rom0VsIYfkjcb2341X2KjYt1OdnXv9FK6obZS139HjL6uF3ZdF1DEw6PB862Bs59X6EO91F5h10mDduXrKs2ZgKrKIvnivyTLIpuWgkFEj-6gN3blTOxDzYBxkRZCjE8__bP2XdG_ZhiBZ1tA-tjs1kmjtP_N5WUpCl5E7uWGU85677DdIQzqcY_q3R5F9vgOq3SQ47DDOMp_ZjzZZNyOS-J23tvwTwy-0p8 |
| CODEN | GERNDJ |
| CitedBy_id | crossref_primary_10_1371_journal_pone_0083518 crossref_primary_10_1016_j_biocel_2013_06_024 crossref_primary_10_6061_clinics_2017_08_07 crossref_primary_10_1186_2046_2395_2_11 crossref_primary_10_3390_jcm9082669 crossref_primary_10_1007_s00424_014_1617_9 crossref_primary_10_1007_s10522_018_9749_5 crossref_primary_10_1155_2016_9057593 crossref_primary_10_1016_j_mam_2016_04_006 crossref_primary_10_1586_erc_12_98 crossref_primary_10_3389_fendo_2019_00255 crossref_primary_10_3390_ijms17060932 crossref_primary_10_1002_jcsm_12051 crossref_primary_10_1111_j_1474_9726_2012_00844_x crossref_primary_10_3390_geriatrics8060121 crossref_primary_10_3390_biomedicines12092096 crossref_primary_10_1016_j_ecoenv_2025_118132 crossref_primary_10_1007_s00018_025_05657_1 crossref_primary_10_1002_ptr_7811 crossref_primary_10_1007_s11626_014_9752_3 crossref_primary_10_1371_journal_pone_0075201 crossref_primary_10_1016_j_exger_2014_12_020 crossref_primary_10_1007_s40520_016_0705_4 crossref_primary_10_1016_j_compbiolchem_2014_10_004 crossref_primary_10_1016_j_exger_2021_111519 crossref_primary_10_1016_j_exger_2017_10_018 crossref_primary_10_1017_S0959259813000154 crossref_primary_10_1007_s40279_015_0305_z crossref_primary_10_1016_j_ijbiomac_2018_04_026 crossref_primary_10_1016_j_mad_2019_111129 crossref_primary_10_1016_j_arr_2015_02_003 crossref_primary_10_3390_ijerph15102301 crossref_primary_10_1016_j_bbadis_2019_165646 crossref_primary_10_1038_s41420_023_01365_6 crossref_primary_10_3390_metabo11050323 crossref_primary_10_1093_jnen_nlab062 crossref_primary_10_1007_s12020_013_0070_4 crossref_primary_10_1007_s12603_018_1057_x crossref_primary_10_3390_antiox7080102 crossref_primary_10_1016_j_bbabio_2015_07_009 crossref_primary_10_1002_mus_23832 crossref_primary_10_3389_fcvm_2022_1038523 crossref_primary_10_1002_dvdy_24036 crossref_primary_10_1007_s00391_015_0986_9 crossref_primary_10_1002_jcsm_13137 crossref_primary_10_1007_s10522_013_9429_4 crossref_primary_10_1016_j_arr_2015_09_005 crossref_primary_10_1016_j_exger_2013_06_005 crossref_primary_10_1155_2019_2860642 crossref_primary_10_3390_ijms21249540 crossref_primary_10_1007_s10522_012_9385_4 crossref_primary_10_1016_j_maturitas_2017_08_009 crossref_primary_10_1186_s12891_024_07568_x crossref_primary_10_2196_59468 crossref_primary_10_3389_fnagi_2015_00013 crossref_primary_10_1172_JCI79197 crossref_primary_10_3390_cancers12071716 crossref_primary_10_3390_fermentation9050429 crossref_primary_10_1097_MCO_0000000000000361 crossref_primary_10_1186_s12891_024_07833_z crossref_primary_10_3389_fnut_2021_731356 crossref_primary_10_12677_TCM_2023_122058 crossref_primary_10_3390_nu14010052 crossref_primary_10_1007_s12603_017_0906_3 crossref_primary_10_1016_j_eurger_2013_02_009 crossref_primary_10_1016_j_jocd_2015_04_011 crossref_primary_10_3390_diagnostics11101879 crossref_primary_10_1016_j_exger_2013_02_012 crossref_primary_10_3390_ijerph19052565 crossref_primary_10_1016_j_exger_2021_111618 crossref_primary_10_1016_j_jss_2016_01_035 crossref_primary_10_3389_fphys_2017_01045 crossref_primary_10_1007_s10522_020_09856_0 crossref_primary_10_1007_s11136_014_0844_z crossref_primary_10_1016_j_amepre_2015_05_025 crossref_primary_10_1016_j_bbadis_2019_165585 crossref_primary_10_1016_j_exger_2013_11_019 crossref_primary_10_3390_ijerph19148866 crossref_primary_10_1002_pmic_201700108 crossref_primary_10_1080_87559129_2022_2087669 crossref_primary_10_37586_2686_8636_3_2024_225_239 crossref_primary_10_1155_2019_9141343 crossref_primary_10_1186_s12986_024_00839_3 crossref_primary_10_1080_13685538_2018_1439004 crossref_primary_10_1016_j_bbagrm_2018_07_011 crossref_primary_10_3389_fcell_2021_671475 crossref_primary_10_1016_j_ecoenv_2025_118100 crossref_primary_10_1016_j_ecoenv_2025_118344 crossref_primary_10_3390_biom13121779 crossref_primary_10_1002_mus_25671 |
| Cites_doi | 10.1089%2Fars.2006.8.517 10.1042%2Fbse0470099 10.1007%2Fs11357-010-9196-y 10.1016%2Fj.mad.2008.12.008 10.1016%2Fj.biocel.2008.02.001 10.1002%2Fbiof.5 10.1016%2Fj.cell.2008.06.051 10.1371%2Fjournal.pone.0010572 10.1158%2F0008-5472.CAN-05-4670 10.1016%2Fj.bbagen.2009.05.007 10.1152%2Fajpregu.00489.2010 10.1038%2Fbjc.1972.33 10.1016%2Fj.freeradbiomed.2003.10.003 10.1016%2Fj.bbrc.2008.05.188 10.1096%2Ffj.09-146308 10.1073%2Fpnas.1019581108 10.1016%2Fj.tiv.2010.06.008 10.1093%2Fageing%2Fafq034 10.1210%2Fen.2009-1177 10.1056%2FNEJM199406233302501 10.1371%2Fjournal.pone.0006430 10.1016%2Fj.abb.2010.05.003 10.1152%2Fajpendo.00095.2006 10.1093%2Fgerona%2F63.4.391 10.1016%2FS0163-7258%2801%2900159-0 10.1096%2Ffj.10-159608 10.1100%2Ftsw.2010.27 10.1073%2Fpnas.0911570106 10.1016%2Fj.cger.2005.12.002 10.1016%2Fj.mad.2008.05.005 10.1152%2Fajpregu.00620.2007 |
| ContentType | Journal Article |
| Copyright | 2011 S. Karger AG, Basel 2014 INIST-CNRS Copyright © 2011 S. Karger AG, Basel. Copyright (c) 2012 S. Karger AG, Basel Copyright © 2011 by S. Karger AG, Basel 2011 |
| Copyright_xml | – notice: 2011 S. Karger AG, Basel – notice: 2014 INIST-CNRS – notice: Copyright © 2011 S. Karger AG, Basel. – notice: Copyright (c) 2012 S. Karger AG, Basel – notice: Copyright © 2011 by S. Karger AG, Basel 2011 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 0-V 3V. 7RV 7TK 7X7 7XB 88E 88G 88I 88J 8AF 8AO 8C1 8FI 8FJ 8FK ABUWG AFKRA ALSLI AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 M0S M1P M2M M2P M2R NAPCQ PHGZM PHGZT PJZUB PKEHL POGQB PPXIY PQEST PQQKQ PQUKI PRINS PRQQA PSYQQ Q9U S0X 7TS 7X8 5PM |
| DOI | 10.1159/000330064 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Social Sciences Premium Collection ProQuest Central (Corporate) Nursing & Allied Health Database Neurosciences Abstracts Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) Social Science Database (Alumni Edition) ProQuest STEM Database ProQuest Pharma Collection Public Health Database (ProQuest) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland Social Science Premium Collection ProQuest Central Essentials - QC ProQuest Central ProQuest One ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection Medical Database ProQuest Psychology Database (ProQuest) Science Database (ProQuest) Social Science Database (ProQuest) Nursing & Allied Health Premium Proquest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest Sociology & Social Sciences Collection ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Social Sciences ProQuest One Psychology ProQuest Central Basic SIRS Editorial Physical Education Index MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Sociology & Social Sciences Collection ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials SIRS Editorial ProQuest Social Science Journals (Alumni Edition) ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection Sociology & Social Sciences Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Social Science Premium Collection ProQuest Public Health ProQuest Science Journals (Alumni Edition) ProQuest One Social Sciences ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Social Science Journals ProQuest Medical Library ProQuest Psychology Journals ProQuest Social Sciences Premium Collection ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) Physical Education Index MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Psychology MEDLINE - Academic CrossRef Physical Education Index MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Social Welfare & Social Work Anatomy & Physiology Public Health |
| EISSN | 1423-0003 |
| EndPage | 106 |
| ExternalDocumentID | PMC7077073 2660691311 21952604 26885737 10_1159_000330064 330064 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: P30 AG028740 |
| GroupedDBID | --- -~X .GJ 0-V 0R~ 0~5 0~B 29H 30W 328 34G 36B 39C 3O. 3V. 4.4 53G 5GY 5RE 7RV 7X7 88E 88I 8AF 8AO 8C1 8FI 8FJ 8UI AAWTL AAYIC ABDNZ ABIVO ABJNI ABPAZ ABUWG ACGFS ACGOD ACNCT ACPRK ACPSR ACYGS ADAGL ADBBV AENEX AEYAO AFDXO AFFNX AFJJK AFKRA AHMBA ALDHI ALIPV ALMA_UNASSIGNED_HOLDINGS ALSLI ARALO AZPMC AZQEC BENPR BKEYQ BPHCQ BVXVI CAG CCPQU COF CS3 CYUIP DWQXO E0A EBS EJD EMB EMOBN EX3 F5P FB. FYUFA GNUQQ HCIFZ HMCUK HZ~ H~9 IAO IHR IHW INH IY7 KUZGX L7B LPU M1P M2M M2P M2R N9A NAPCQ O1H O9- PQQKQ PROAC PSQYO PSYQQ RIG RKO RXVBD S0X SV3 TWZ UJ6 UKHRP UPT WH7 WOW X7L YCJ ZGI ZXP AAYXX ABBTS ABWCG ACQXL AFFHD AFSIO AHFRZ CITATION ITC PHGZM PHGZT PJZUB PPXIY PRQQA AEILP IQODW CGR CUY CVF ECM EIF NPM Z5M 7TK 7XB 8FK K9. PKEHL POGQB PQEST PQUKI PRINS Q9U 7TS PUEGO 7X8 5PM |
| ID | FETCH-LOGICAL-c517t-e76de6ce6e80cbe90df28b60f814230601a9d37a1d2887306ab3159c5ffc01d3 |
| IEDL.DBID | M2P |
| ISICitedReferencesCount | 118 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000300755100002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0304-324X 1423-0003 |
| IngestDate | Tue Nov 04 01:48:14 EST 2025 Wed Oct 01 14:58:42 EDT 2025 Thu Oct 02 06:48:59 EDT 2025 Sun Nov 16 03:56:17 EST 2025 Wed Feb 19 02:30:47 EST 2025 Mon Jul 21 09:16:54 EDT 2025 Tue Nov 18 22:40:14 EST 2025 Sat Nov 29 07:58:14 EST 2025 Thu Aug 29 12:04:35 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Angiotensin-converting enzyme inhibitors Mitochondria Exercise Calorie restriction Resveratrol Muscle Hormones Physical exercise Senescence Enzyme inhibitor Review Antioxidant Striated muscle Stilbene derivatives Myocyte Sarcopenia Renin angiotensin system Vertebrata Mammalia Angiotensin Apoptosis |
| Language | English |
| License | Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. https://www.karger.com/Services/SiteLicenses CC BY 4.0 Copyright © 2011 S. Karger AG, Basel. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c517t-e76de6ce6e80cbe90df28b60f814230601a9d37a1d2887306ab3159c5ffc01d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Review-3 |
| PMID | 21952604 |
| PQID | 1013527553 |
| PQPubID | 33168 |
| PageCount | 8 |
| ParticipantIDs | proquest_journals_1013527553 pubmed_primary_21952604 crossref_primary_10_1159_000330064 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7077073 proquest_miscellaneous_1492628510 crossref_citationtrail_10_1159_000330064 proquest_miscellaneous_926150994 karger_primary_330064 pascalfrancis_primary_26885737 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-02-00 |
| PublicationDateYYYYMMDD | 2012-02-01 |
| PublicationDate_xml | – month: 02 year: 2012 text: 2012-02-00 |
| PublicationDecade | 2010 |
| PublicationPlace | Basel, Switzerland |
| PublicationPlace_xml | – name: Basel, Switzerland – name: Basel – name: Switzerland – name: Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.com |
| PublicationTitle | Gerontology (Basel) |
| PublicationTitleAlternate | Gerontology |
| PublicationYear | 2012 |
| Publisher | Karger S. Karger AG |
| Publisher_xml | – name: Karger – name: S. Karger AG |
| References | Dirks AJ, Leeuwenburgh C: Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Free Radic Biol Med 2004;36:27–39.1473228810.1016%2Fj.freeradbiomed.2003.10.003 Marzetti E, Wohlgemuth SE, Lees HA, Chung HY, Giovannini S, Leeuwenburgh C: Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mech Ageing Dev 2008;129:542–549.10.1016%2Fj.mad.2008.05.005 Argiles JM, Lopez-Soriano FJ, Busquets S: Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions. Int J Biochem Cell Biol 2008;40:1674–1678.10.1016%2Fj.biocel.2008.02.001 Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci USA 2011;108:4135–4140.10.1073%2Fpnas.1019581108 Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM: AMPK and PPARdelta agonists are exercise mimetics. Cell 2008;134:405–415.1867480910.1016%2Fj.cell.2008.06.051 Frankel JE, Bean JF, Frontera WR: Exercise in the elderly: research and clinical practice. Clin Geriatr Med 2006;22:239–256.10.1016%2Fj.cger.2005.12.002 Ekhterae D, Lin Z, Lundberg MS, Crow MT, Brosius FC, III, Nunez G: ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circ Res 1999;85:e70–e77. Walston J, Fedarko N, Yang H, Leng S, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K: The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci 2008;63:391–398.10.1093%2Fgerona%2F63.4.391 Phillips T, Leeuwenburgh C: Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J 2005;19:668–670. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE: Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 2004;113:115–123.14702115 Marzetti E, Privitera G, Simili V, Wohlgemuth SE, Aulisa L, Pahor M, Leeuwenburgh C: Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging. Scientific World J 2010;10:340–349.10.1100%2Ftsw.2010.27 Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I: Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys 2010;501:79–90.10.1016%2Fj.abb.2010.05.003 Kujoth GC, Leeuwenburgh C, Prolla TA: Mitochondrial DNA mutations and apoptosis in mammalian aging. Cancer Res 2006;66:7386–7389.10.1158%2F0008-5472.CAN-05-4670 Marzetti E, Carter CS, Wohlgemuth SE, Lees HA, Giovannini S, Anderson B, Quinn LS, Leeuwenburgh C: Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mech Ageing Dev 2009;130:272–280.10.1016%2Fj.mad.2008.12.008 Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT: Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 2009;106:20405–20410.1991807510.1073%2Fpnas.0911570106 Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239–257.456102710.1038%2Fbjc.1972.33 Fiatarone MA, O’Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ: Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994;330:1769–1775.819015210.1056%2FNEJM199406233302501 Siddiqui MA, Kashyap MP, Kumar V, Al-Khedhairy AA, Musarrat J, Pant AB: Protective potential of trans-resveratrol against 4-hydroxynonenal induced damage in PC12 cells. Toxicol In Vitro 2010;24:1592–1598.10.1016%2Fj.tiv.2010.06.008 Marzetti E, Hwang JC, Lees HA, Wohlgemuth SE, Dupont-Versteegden EE, Carter CS, Bernabei R, Leeuwenburgh C: Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta 2010;1800:235–244.10.1016%2Fj.bbagen.2009.05.007 Xu J, Seo AY, Vorobyeva DA, Carter CS, Anton SD, Lezza AM, Leeuwenburgh C: Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PLoS One 2010;5:e10572.10.1371%2Fjournal.pone.0010572 Landi F, Zuccala G, Gambassi G, Incalzi RA, Manigrasso L, Pagano F, Carbonin P, Bernabei R: Body mass index and mortality among older people living in the community. J Am Geriatr Soc 1999;47:1072–1076.10484248 Song W, Kwak HB, Lawler JM: Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle. Antioxid Redox Signal 2006;8:517–528.10.1089%2Fars.2006.8.517 Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ: Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab 2006;291:E1341–E1350.10.1152%2Fajpendo.00095.2006 Murphy KT, Koopman R, Naim T, Leger B, Trieu J, Ibebunjo C, Lynch GS: Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function. FASEB J 2010;24:4433–4442.10.1096%2Ffj.10-159608 Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M: Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412–423.10.1093%2Fageing%2Fafq034 Carter CS, Giovaninni S, Seo DO, Dupree J, Morgan D, Chung HY, Lees H, Daniels M, Hubbard GB, Lee S, Ikeno Y, Foster TC, Buford TW, Marzetti E: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age (Dordr) 2011;33:167–183.10.1007%2Fs11357-010-9196-y Roubenoff R: Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging 2000;4:140–142. Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van RH: Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J 2010;24:1376–1390.10.1096%2Ffj.09-146308 Zimmermann KC, Bonzon C, Green DR: The machinery of programmed cell death. Pharmacol Ther 2001;92:57–70.10.1016%2FS0163-7258%2801%2900159-0 Marzetti E, Groban L, Wohlgemuth SE, Lees HA, Lin M, Jobe H, Giovannini S, Leeuwenburgh C, Carter CS: Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol 2008;294: R558–R567.10.1152%2Fajpregu.00620.2007 Parsons MJ, Green DR: Mitochondria in cell death. Essays Biochem 2010;47:99–114.10.1042%2Fbse0470099 Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I: Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology 2010;151:628–638.10.1210%2Fen.2009-1177 Pistilli EE, Alway SE: Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats. Biochem Biophys Res Commun 2008;373:20–24.10.1016%2Fj.bbrc.2008.05.188 Jackson JR, Ryan MJ, Hao Y, Alway SE: Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats. Am J Physiol Regul Integr Comp Physiol 2010;299:R1572–R1581.10.1152%2Fajpregu.00489.2010 Wu M, Katta A, Gadde MK, Liu H, Kakarla SK, Fannin J, Paturi S, Arvapalli RK, Rice KM, Wang Y, Blough ER: Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS One 2009;4:e6430.10.1371%2Fjournal.pone.0006430 Marzetti E, Lees HA, Wohlgemuth SE, Leeuwenburgh C: Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction. Bio Factors 2009;35:28–35.1931984310.1002%2Fbiof.5 ref13 ref12 ref15 ref14 ref31 ref30 ref11 ref10 ref2 ref1 ref17 ref16 ref19 ref18 ref24 ref23 ref26 ref25 ref20 ref22 ref21 ref28 ref27 ref29 ref8 ref7 ref9 ref4 ref3 ref6 ref5 |
| References_xml | – reference: Marzetti E, Privitera G, Simili V, Wohlgemuth SE, Aulisa L, Pahor M, Leeuwenburgh C: Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging. Scientific World J 2010;10:340–349.10.1100%2Ftsw.2010.27 – reference: Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239–257.456102710.1038%2Fbjc.1972.33 – reference: Parsons MJ, Green DR: Mitochondria in cell death. Essays Biochem 2010;47:99–114.10.1042%2Fbse0470099 – reference: Marzetti E, Carter CS, Wohlgemuth SE, Lees HA, Giovannini S, Anderson B, Quinn LS, Leeuwenburgh C: Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mech Ageing Dev 2009;130:272–280.10.1016%2Fj.mad.2008.12.008 – reference: Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE: Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 2004;113:115–123.14702115 – reference: Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ: Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab 2006;291:E1341–E1350.10.1152%2Fajpendo.00095.2006 – reference: Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT: Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 2009;106:20405–20410.1991807510.1073%2Fpnas.0911570106 – reference: Argiles JM, Lopez-Soriano FJ, Busquets S: Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions. Int J Biochem Cell Biol 2008;40:1674–1678.10.1016%2Fj.biocel.2008.02.001 – reference: Jackson JR, Ryan MJ, Hao Y, Alway SE: Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats. Am J Physiol Regul Integr Comp Physiol 2010;299:R1572–R1581.10.1152%2Fajpregu.00489.2010 – reference: Kujoth GC, Leeuwenburgh C, Prolla TA: Mitochondrial DNA mutations and apoptosis in mammalian aging. Cancer Res 2006;66:7386–7389.10.1158%2F0008-5472.CAN-05-4670 – reference: Marzetti E, Wohlgemuth SE, Lees HA, Chung HY, Giovannini S, Leeuwenburgh C: Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mech Ageing Dev 2008;129:542–549.10.1016%2Fj.mad.2008.05.005 – reference: Zimmermann KC, Bonzon C, Green DR: The machinery of programmed cell death. Pharmacol Ther 2001;92:57–70.10.1016%2FS0163-7258%2801%2900159-0 – reference: Xu J, Seo AY, Vorobyeva DA, Carter CS, Anton SD, Lezza AM, Leeuwenburgh C: Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PLoS One 2010;5:e10572.10.1371%2Fjournal.pone.0010572 – reference: Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I: Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys 2010;501:79–90.10.1016%2Fj.abb.2010.05.003 – reference: Ekhterae D, Lin Z, Lundberg MS, Crow MT, Brosius FC, III, Nunez G: ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circ Res 1999;85:e70–e77. – reference: Marzetti E, Groban L, Wohlgemuth SE, Lees HA, Lin M, Jobe H, Giovannini S, Leeuwenburgh C, Carter CS: Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol 2008;294: R558–R567.10.1152%2Fajpregu.00620.2007 – reference: Murphy KT, Koopman R, Naim T, Leger B, Trieu J, Ibebunjo C, Lynch GS: Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function. FASEB J 2010;24:4433–4442.10.1096%2Ffj.10-159608 – reference: Song W, Kwak HB, Lawler JM: Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle. Antioxid Redox Signal 2006;8:517–528.10.1089%2Fars.2006.8.517 – reference: Roubenoff R: Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging 2000;4:140–142. – reference: Frankel JE, Bean JF, Frontera WR: Exercise in the elderly: research and clinical practice. Clin Geriatr Med 2006;22:239–256.10.1016%2Fj.cger.2005.12.002 – reference: Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM: AMPK and PPARdelta agonists are exercise mimetics. Cell 2008;134:405–415.1867480910.1016%2Fj.cell.2008.06.051 – reference: Wu M, Katta A, Gadde MK, Liu H, Kakarla SK, Fannin J, Paturi S, Arvapalli RK, Rice KM, Wang Y, Blough ER: Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS One 2009;4:e6430.10.1371%2Fjournal.pone.0006430 – reference: Dirks AJ, Leeuwenburgh C: Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Free Radic Biol Med 2004;36:27–39.1473228810.1016%2Fj.freeradbiomed.2003.10.003 – reference: Marzetti E, Lees HA, Wohlgemuth SE, Leeuwenburgh C: Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction. Bio Factors 2009;35:28–35.1931984310.1002%2Fbiof.5 – reference: Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I: Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology 2010;151:628–638.10.1210%2Fen.2009-1177 – reference: Phillips T, Leeuwenburgh C: Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J 2005;19:668–670. – reference: Landi F, Zuccala G, Gambassi G, Incalzi RA, Manigrasso L, Pagano F, Carbonin P, Bernabei R: Body mass index and mortality among older people living in the community. J Am Geriatr Soc 1999;47:1072–1076.10484248 – reference: Siddiqui MA, Kashyap MP, Kumar V, Al-Khedhairy AA, Musarrat J, Pant AB: Protective potential of trans-resveratrol against 4-hydroxynonenal induced damage in PC12 cells. Toxicol In Vitro 2010;24:1592–1598.10.1016%2Fj.tiv.2010.06.008 – reference: Fiatarone MA, O’Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ: Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994;330:1769–1775.819015210.1056%2FNEJM199406233302501 – reference: Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van RH: Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J 2010;24:1376–1390.10.1096%2Ffj.09-146308 – reference: Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M: Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412–423.10.1093%2Fageing%2Fafq034 – reference: Marzetti E, Hwang JC, Lees HA, Wohlgemuth SE, Dupont-Versteegden EE, Carter CS, Bernabei R, Leeuwenburgh C: Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta 2010;1800:235–244.10.1016%2Fj.bbagen.2009.05.007 – reference: Pistilli EE, Alway SE: Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats. Biochem Biophys Res Commun 2008;373:20–24.10.1016%2Fj.bbrc.2008.05.188 – reference: Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci USA 2011;108:4135–4140.10.1073%2Fpnas.1019581108 – reference: Carter CS, Giovaninni S, Seo DO, Dupree J, Morgan D, Chung HY, Lees H, Daniels M, Hubbard GB, Lee S, Ikeno Y, Foster TC, Buford TW, Marzetti E: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age (Dordr) 2011;33:167–183.10.1007%2Fs11357-010-9196-y – reference: Walston J, Fedarko N, Yang H, Leng S, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K: The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci 2008;63:391–398.10.1093%2Fgerona%2F63.4.391 – ident: ref19 doi: 10.1089%2Fars.2006.8.517 – ident: ref10 doi: 10.1042%2Fbse0470099 – ident: ref22 doi: 10.1007%2Fs11357-010-9196-y – ident: ref6 doi: 10.1016%2Fj.mad.2008.12.008 – ident: ref11 doi: 10.1016%2Fj.biocel.2008.02.001 – ident: ref12 doi: 10.1002%2Fbiof.5 – ident: ref21 doi: 10.1016%2Fj.cell.2008.06.051 – ident: ref25 doi: 10.1371%2Fjournal.pone.0010572 – ident: ref28 doi: 10.1158%2F0008-5472.CAN-05-4670 – ident: ref3 doi: 10.1016%2Fj.bbagen.2009.05.007 – ident: ref16 doi: 10.1152%2Fajpregu.00489.2010 – ident: ref8 doi: 10.1038%2Fbjc.1972.33 – ident: ref13 doi: 10.1016%2Fj.freeradbiomed.2003.10.003 – ident: ref27 doi: 10.1016%2Fj.bbrc.2008.05.188 – ident: ref30 doi: 10.1096%2Ffj.09-146308 – ident: ref29 doi: 10.1073%2Fpnas.1019581108 – ident: ref15 doi: 10.1016%2Fj.tiv.2010.06.008 – ident: ref1 doi: 10.1093%2Fageing%2Fafq034 – ident: ref26 doi: 10.1210%2Fen.2009-1177 – ident: ref18 doi: 10.1056%2FNEJM199406233302501 – ident: ref23 doi: 10.1371%2Fjournal.pone.0006430 – ident: ref14 doi: 10.1016%2Fj.abb.2010.05.003 – ident: ref7 doi: 10.1152%2Fajpendo.00095.2006 – ident: ref4 doi: 10.1093%2Fgerona%2F63.4.391 – ident: ref9 doi: 10.1016%2FS0163-7258%2801%2900159-0 – ident: ref24 doi: 10.1096%2Ffj.10-159608 – ident: ref2 doi: 10.1100%2Ftsw.2010.27 – ident: ref31 doi: 10.1073%2Fpnas.0911570106 – ident: ref17 doi: 10.1016%2Fj.cger.2005.12.002 – ident: ref5 doi: 10.1016%2Fj.mad.2008.05.005 – ident: ref20 doi: 10.1152%2Fajpregu.00620.2007 |
| SSID | ssj0030210 |
| Score | 2.3589334 |
| SecondaryResourceType | review_article |
| Snippet | Background: Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental... Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref karger |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 99 |
| SubjectTerms | Age Age differences Aged Aging Animals Antibodies Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis - physiology Atrophy Biological and medical sciences Caloric Restriction Cell Nucleus - pathology Cells Clinical Section / Mini-Review Development. Metamorphosis. Moult. Ageing Diet Drug therapy Drugs Elimination Exercise Exercise Therapy Frail Elderly Frailty Function Fundamental and applied biological sciences. Psychology Genetics Hormones Humans Intervention Literature reviews Models, Biological Morality Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - pathology Muscle Fibers, Skeletal - physiology Musculoskeletal diseases Novels Physical ability Preservation Property Public health Sarcopenia Sarcopenia - pathology Sarcopenia - physiopathology Sarcopenia - prevention & control Sarcopenia - therapy Signal Transduction - physiology Signaling Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | Apoptosis in Skeletal Myocytes: A Potential Target for Interventions against Sarcopenia and Physical Frailty – A Mini-Review |
| URI | https://karger.com/doi/10.1159/000330064 https://www.ncbi.nlm.nih.gov/pubmed/21952604 https://www.proquest.com/docview/1013527553 https://www.proquest.com/docview/1492628510 https://www.proquest.com/docview/926150994 https://pubmed.ncbi.nlm.nih.gov/PMC7077073 |
| Volume | 58 |
| WOSCitedRecordID | wos000300755100002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: 7X7 dateStart: 19940101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: 7RV dateStart: 19940101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: BENPR dateStart: 19940101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database (ProQuest) customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: M2M dateStart: 19940101 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: 8C1 dateStart: 19940101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: M2P dateStart: 19940101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Social Science Database (ProQuest) customDbUrl: eissn: 1423-0003 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0030210 issn: 0304-324X databaseCode: M2R dateStart: 19940101 isFulltext: true titleUrlDefault: https://search.proquest.com/socscijournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3di9NAEB-8D0QQP3qnVmtZRcSXQJJtsokvUo87FGwpvUP7Vrb7oaE1qU1OKPjHO7ub5K5y-iKUedidNJtkduc3O7MzAK9Y4i_iNFKeHMTUGCjCS7QWnmSoXykNOeP2oPAnNh4ns1k6qTfcyjqsslkT7UItC2H2yHF2B4gVWBTRd-sfnqkaZbyrdQmNPThAZBOYkK5ROGlWYmrsGedFGHgIHGZ1ZiHU4OYAA1ryfjzY0UeHSxN-vTEBkrzEd6RdcYub0OefQZTXtNLZ_f99ngdwr8ajZOgE6CHcUnkHjoY52uLft-Q1sRGiduu9A7dHtSO-A3fddh9xp5g60HPHfMkXtdJ8o_DCpqHYLI_g13BdrKuizEqS5eR8iboOQT8ZbQuxRaz7lgzJpKhM4BK2XtjgdIJomny8FpFZEv6VZ4hmyTlOTlP1K-OE59INEV8jQRCeraot8fDvRlmeec7xcQwXZ6cXJx-8uu6DJ6KAVZ5isVSxULFKfLFQqS91mCxiXyfBwFhMfsBTSRkPZIhLJDbwBcVvKiIUMj-Q9BHs50WungDxOdcpTXSkYzrQoUg1DTQXoRRigZas7MKb5uPPRZ0T3ZTmWM2tbRSl81ZOuvCyZV27RCA3MR07CWpZmvb-jkC13WGcJBGjrAu9Rkrm9SJSzq9EpAsv2m6c_sanw3NVXCKPTfiIsNnvAvkLD3Ig7E9THMZjJ7NX9w_SCC1a7GE70twymOzjuz159s1mIWc-wx99-u-RP4M7CDFDF-feg_1qc6mew6H4WWXlpg97bPrZ0BmzNEGanAR9OHh_Op5M-2Y6jyydWDr9DS8ZT2Y |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwED-NMQES4qPboFCGQQzxEimJmzhBQqgCplVrq0qrRN8i17FZ1JKUJgNV4l_if-QcJ9mKBm97QMqTfUkc-z7jn-8AXrHAnvmhJ62461MdoAgrUEpYMUP7SqnLGS8PCg_YaBRMp-F4C37VZ2E0rLLWiaWijjOh_5GjdDvoKzDPo--X3yxdNUrvrtYlNAxbnMj1DwzZ8nf9j7i-h6579Gny4diqqgpYwnNYYUnmx9IX0peBLWYytGPlBjPfVoHT1f647fAwpow7sYsCiA18RtHmCw8_wXZiio-9ATe7OrGYRgq641rxUx0-mU2LroV-yrRKZIQ36_MSlGrzv2H-duYa7b3SeEye45IoU0vjKmf3T8zmJSN4dP8_m74HcK_ytknPiMdD2JJpC3Z7KS-yr2vympT413JjoQW3hhXMoAV3zc9MYs5otaBjDjGTz3Kh-ErijXVDtprvws_eMlsWWZ7kJEnJ6RwtOYY0ZLjOxBo9-bekR8ZZoWFZ2DopofcEYwXSv4Q3zQn_whP01ckpTpKuaZZwwtPYDBFXjWCIkSyKNbHwccMkTSyzrbMHk-uYwH3YTrNUPgZic65CGihP-bSrXBEq6igu3FiIGbJn3IY3Na9Fosr4rguPLKIy8vPCqGHLNrxsSJcmzclVRHuGYRuSuv1gg3-bbtcPAo9R1oZOzZRRpSLz6IIj2_Ci6UblpneseCqzc6Qp01liUGC3gfyFBikwqAlDHMYjIyIX73dCD-N17GEbwtMQ6Nzqmz1pclbmWGc2w4s--ffIn8Pt48lwEA36o5OncAedadcg-juwXazO5TPYEd-LJF8dlJqCQHTNovUbbJKkPQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3fb9MwED6NbpqQED-6AYUyDALES0QSN3GChFBhq6i2VhWrRN8i17EhaklKk4Eq8Y_x33GOk25Fg7c9IPXJvqSOc-e7L_58B_CMBfbUDz1pxR2faoAirEApYcUM_SulLme8PCh8wobDYDIJR1vwqz4Lo2mV9ZpYLtRxJvQ3crRuB2MF5nn0lapoEaPD3tvFN0tXkNI7rXU5DaMix3L1A-Fb_qZ_iO_6uev2jsbvP1hVhQFLeA4rLMn8WPpC-jKwxVSGdqzcYOrbKnA6Oja3HR7GlHEndtEYsYFPKfp_4eHj2E5M8bbXYJthjNFpwPa7o-HoY-0GqAZTZgujY2HUMqnSGuHl-vQEpToY2HCGOzPN_V5qdibP8QUpU1njstD3TwbnBZfYu_UfT-ZtuFnF4aRrDOcObMm0CXvdlBfZ1xV5QUpmbLnl0ITdQUVAaMIN85mTmNNbTWib483kk5wrvpR4Yd2QLWd78LO7yBZFlic5SVJyOkMfj2CHDFaZWGGM_5p0ySgrNGELW8clKZ8giiD9C0zUnPDPPMEonpziJOlqZwknPI3NEPENEgQfybxYEQtvN0jSxDIbPvswvooJvAuNNEvlfSA25yqkgfKUTzvKFaGijuLCjYWYIoKPW_Cy1rtIVLngdUmSeVRiQi-M1iragqdr0YVJgHKZ0L5R3rVI3X6wocvrbtcPAo9R1oJ2raBRtXjm0bl2tuDJuhuXPb2XxVOZnaFMmegS4YLdAvIXGZRAuBOGOIx7xlzO_98JPUTy2MM2DGktoLOub_akyZcy-zqzGf7og3-P_DHsokVFJ_3h8UO4jlG2a6j-bWgUyzP5CHbE9yLJlwfVskEgumLb-g3nfK5X |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Apoptosis+in+skeletal+myocytes%3A+a+potential+target+for+interventions+against+sarcopenia+and+physical+frailty+-+a+mini-review&rft.jtitle=Gerontology+%28Basel%29&rft.au=Marzetti%2C+Emanuele&rft.au=Calvani%2C+Riccardo&rft.au=Bernabei%2C+Roberto&rft.au=Leeuwenburgh%2C+Christiaan&rft.date=2012-02-01&rft.issn=1423-0003&rft.eissn=1423-0003&rft.volume=58&rft.issue=2&rft.spage=99&rft_id=info:doi/10.1159%2F000330064&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-324X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-324X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-324X&client=summon |