Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

Dendritic cells (DCs) and monocytes are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these cells may contribute to immunopathology. Here, we performed high-dimensional flow cytometry-analysis focusing on mononuclear phagocyte (MNP) li...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 118; H. 6
Hauptverfasser:	Kvedaraite, Egle, Hertwig, Laura, Sinha, Indranil, Ponzetta, Andrea, Hed Myrberg, Ida, Lourda, Magda, Dzidic, Majda, Akber, Mira, Klingström, Jonas, Folkesson, Elin, Muvva, Jagadeeswara Rao, Chen, Puran, Gredmark-Russ, Sara, Brighenti, Susanna, Norrby-Teglund, Anna, Eriksson, Lars I, Rooyackers, Olav, Aleman, Soo, Strålin, Kristoffer, Ljunggren, Hans-Gustaf, Ginhoux, Florent, Björkström, Niklas K, Henter, Jan-Inge, Svensson, Mattias
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 09.02.2021
Schlagworte:	Adult COVID-19 - epidemiology COVID-19 - immunology COVID-19 - metabolism COVID-19 - virology Cytokines - immunology Dendritic Cells - immunology Female Humans Interferons - immunology Male Middle Aged Monocytes - immunology Mononuclear Phagocyte System - immunology Mononuclear Phagocyte System - metabolism SARS-CoV-2 - immunology Severity of Illness Index Sweden Sweden COVID-19 monocytes DCs pre-DCs
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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