More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

The genus comprises 65 species, among which is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally analyzed 80 genomes spanning 58 species. Uniquely, an immense repository of 18,000 secreted proteins encodin...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 6; p. 2265
Main Authors:	Gomez-Valero, Laura, Rusniok, Christophe, Carson, Danielle, Mondino, Sonia, Pérez-Cobas, Ana Elena, Rolando, Monica, Pasricha, Shivani, Reuter, Sandra, Demirtas, Jasmin, Crumbach, Johannes, Descorps-Declere, Stephane, Hartland, Elizabeth L, Jarraud, Sophie, Dougan, Gordon, Schroeder, Gunnar N, Frankel, Gad, Buchrieser, Carmen
Format:	Journal Article
Language:	English
Published:	United States 05.02.2019
Subjects:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Secretion Systems - genetics Computational Biology - methods Evolution, Molecular Genome, Bacterial Genomics - methods Humans Intracellular Space - microbiology Legionella - classification Legionella - physiology Legionellosis - microbiology Phylogeny Protein Domains Legionella human pathogen horizontal gene transfer coevolution protozoa
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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