The impact of enteral feeding and therapeutic monitoring of rifampicin with dose escalation in critically ill patients with tuberculosis

•Rifampicin concentrations were low in all continuously fed critically ill patients.•Dose escalation increased drug exposure and achieved target concentrations.•Therapeutic drug monitoring should be implemented in critically ill patients to improve dose optimization.•Further research is required to...

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Bibliographic Details
Published in:	International journal of infectious diseases Vol. 126; pp. 174 - 180
Main Authors:	Perumal, Rubeshan, Naidoo, Kogieleum, Naidoo, Anushka, Letsoalo, Marothi P., Esmail, Aliasgar, Joubert, Ivan, Denti, Paolo, Wiesner, Lubbe, Padayatchi, Nesri, Maartens, Gary, Dheda, Keertan
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01.01.2023 Elsevier
Subjects:	Critical Illness Dose-adjustment Drug Monitoring Drug Therapy, Combination Enteral Nutrition High-dose rifampicin Humans Personalized medicine Pharmacokinetics Rifampin Tuberculosis - drug therapy High-dose rifampicin Critical illness Pharmacokinetics Personalized medicine Dose-adjustment
ISSN:	1201-9712, 1878-3511, 1878-3511
Online Access:	Get full text
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