Tumor cell dissemination: emerging biological insights from animal models and cancer patients

Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the s...

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Bibliographic Details
Published in:Cancer cell Vol. 23; no. 5; p. 573
Main Authors: Kang, Yibin, Pantel, Klaus
Format: Journal Article
Language:English
Published: United States 13.05.2013
Subjects:
Animals
Cell Survival
Disease Models, Animal
Epithelial-Mesenchymal Transition - genetics
Humans
Mice
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Neoplasm Metastasis
Neoplastic Cells, Circulating - pathology
ISSN:1878-3686, 1878-3686
Online Access:Get more information
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Summary:Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.
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ISSN:1878-3686
1878-3686
DOI:10.1016/j.ccr.2013.04.017