Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting their efficacy in clinical trials against hematologic...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Blood Ročník 136; číslo 10; s. 1155
Hlavní autori:	Fultang, Livingstone, Booth, Sarah, Yogev, Orli, Martins da Costa, Barbara, Tubb, Vanessa, Panetti, Silvia, Stavrou, Victoria, Scarpa, Ugo, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Lee, Steven P, Dunn, Warwick B, Chesler, Louis, Mussai, Francis, De Santo, Carmela
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 03.09.2020
Predmet:	Animals Apoptosis Arginine - metabolism Argininosuccinate Synthase - genetics Argininosuccinate Synthase - metabolism Cell Proliferation Humans Immunotherapy, Adoptive - methods Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Metabolic Engineering - methods Mice Mice, Nude Neuroblastoma - immunology Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - therapy Ornithine Carbamoyltransferase - genetics Ornithine Carbamoyltransferase - metabolism Receptors, Chimeric Antigen - chemistry Receptors, Chimeric Antigen - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - transplantation Tumor Cells, Cultured Xenograft Model Antitumor Assays
ISSN:	1528-0020, 1528-0020
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!