Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting their efficacy in clinical trials against hematologic...

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Bibliographic Details
Published in:	Blood Vol. 136; no. 10; p. 1155
Main Authors:	Fultang, Livingstone, Booth, Sarah, Yogev, Orli, Martins da Costa, Barbara, Tubb, Vanessa, Panetti, Silvia, Stavrou, Victoria, Scarpa, Ugo, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Lee, Steven P, Dunn, Warwick B, Chesler, Louis, Mussai, Francis, De Santo, Carmela
Format:	Journal Article
Language:	English
Published:	United States 03.09.2020
Subjects:	Animals Apoptosis Arginine - metabolism Argininosuccinate Synthase - genetics Argininosuccinate Synthase - metabolism Cell Proliferation Humans Immunotherapy, Adoptive - methods Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Metabolic Engineering - methods Mice Mice, Nude Neuroblastoma - immunology Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - therapy Ornithine Carbamoyltransferase - genetics Ornithine Carbamoyltransferase - metabolism Receptors, Chimeric Antigen - chemistry Receptors, Chimeric Antigen - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - transplantation Tumor Cells, Cultured Xenograft Model Antitumor Assays
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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