Interactions of particulate matter and pulmonary surfactant: Implications for human health

Particulate matter (PM), which is the primary contributor to air pollution, has become a pervasive global health threat. When PM enters into a respiratory tract, the first body tissues to be directly exposed are the cells of respiratory tissues and pulmonary surfactant. Pulmonary surfactant is a piv...

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Bibliographic Details
Published in:Advances in colloid and interface science Vol. 284; p. 102244
Main Authors: Wang, Feifei, Liu, Jifang, Zeng, Hongbo
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.10.2020
Published by Elsevier B.V
Subjects:
Animals
Health
Historical
Humans
Monolayer
Nanoparticles - chemistry
Particulate matter
Particulate Matter - chemistry
Particulate Matter - metabolism
Particulate Matter - toxicity
Pulmonary surfactant
Pulmonary Surfactants - metabolism
Surface interaction
Monolayer
Surface interaction
Pulmonary surfactant
Particulate matter
ISSN:0001-8686, 1873-3727, 1873-3727
Online Access:Get full text
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Summary:Particulate matter (PM), which is the primary contributor to air pollution, has become a pervasive global health threat. When PM enters into a respiratory tract, the first body tissues to be directly exposed are the cells of respiratory tissues and pulmonary surfactant. Pulmonary surfactant is a pivotal component to modulate surface tension of alveoli during respiration. Many studies have proved that PM would interact with pulmonary surfactant to affect the alveolar activity, and meanwhile, pulmonary surfactant would be adsorbed to the surface of PM to change the toxic effect of PM. This review focuses on recent studies of the interactions between micro/nanoparticles (synthesized and environmental particles) and pulmonary surfactant (natural surfactant and its models), as well as the health effects caused by PM through a few significant aspects, such as surface properties of PM, including size, surface charge, hydrophobicity, shape, chemical nature, etc. Moreover, in vitro and in vivo studies have shown that PM leads to oxidative stress, inflammatory response, fibrosis, and cancerization in living bodies. By providing a comprehensive picture of PM-surfactant interaction, this review will benefit both researchers for further studies and policy-makers for setting up more appropriate regulations to reduce the adverse effects of PM on public health. [Display omitted] •Long-term exposure to particulate matter (PM) reduces life expectancy.•Pulmonary surfactant is the initial tissues contacted with PM.•The interaction behaviors of PM and pulmonary surfactant are systematically reviewed.•Surface properties of PM determine PM-surfactant interactions.
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ISSN:0001-8686
1873-3727
1873-3727
DOI:10.1016/j.cis.2020.102244