Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor

Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor...

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Vydané v:	Cancer cell Ročník 26; číslo 2; s. 222
Hlavní autori:	Lu, Gang, Zhang, Qing, Huang, Ying, Song, Jiaxi, Tomaino, Ross, Ehrenberger, Tobias, Lim, Elgene, Liu, Wenbin, Bronson, Roderick T, Bowden, Michaela, Brock, Jane, Krop, Ian E, Dillon, Deborah A, Gygi, Steven P, Mills, Gordon B, Richardson, Andrea L, Signoretti, Sabina, Yaffe, Michael B, Kaelin, Jr, William G
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 11.08.2014
Predmet:	Amino Acid Sequence Animals Binding Sites Female HCT116 Cells HEK293 Cells Humans Mice Mice, Inbred NOD Mice, SCID Molecular Sequence Data Neoplasm Transplantation Phosphorylation Protein Binding Proto-Oncogene Protein c-ets-1 - metabolism Proto-Oncogene Protein c-ets-2 - metabolism src-Family Kinases - metabolism Triple Negative Breast Neoplasms - enzymology Triple Negative Breast Neoplasms - pathology Tumor Burden Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination
ISSN:	1878-3686, 1878-3686
On-line prístup:	Zistit podrobnosti o prístupe
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