Flow cytometry based platelet activation markers and state of inflammation among subjects with type 2 diabetes with and without depression

Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are highly disabling disorders associated with a multitude of vascular complications. Platelets are known to play a role in the pathogenesis of vascular complications in both T2DM and MDD. These complications could increase in patie...

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Vydáno v:Scientific reports Ročník 12; číslo 1; s. 10039 - 9
Hlavní autoři: R, Shyamkrishnan, Saharia, Gautom Kumar, Patra, Suravi, Bandyopadhyay, Debapriya, Patro, Binod Kumar
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 16.06.2022
Nature Publishing Group
Nature Portfolio
Témata:
631/378
631/45
CD63 antigen
Comorbidity
Diabetes
Diabetes mellitus (non-insulin dependent)
Flow cytometry
Humanities and Social Sciences
Inflammation
Insulin
Mental depression
multidisciplinary
Platelets
Science
Science (multidisciplinary)
ISSN:2045-2322, 2045-2322
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Shrnutí:Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are highly disabling disorders associated with a multitude of vascular complications. Platelets are known to play a role in the pathogenesis of vascular complications in both T2DM and MDD. These complications could increase in patients with comorbid diabetes and depression. To quantify and compare flow cytometry based platelet activation markers and the inflammatory state between individuals of diabetes with depression, individuals of diabetes without depression and healthy controls. Out of 114 participants, each study group contained 38 participants in diabetic group, diabetics with depression group and matched control group. Diabetes was diagnosed with the American Diabetes Association (ADA) criteria. Screening of MDD was done with Patient Health Questionnaire 2 (PHQ2) and severity of depression assessed with Hamilton Depression Rating (HAM-D) scale. Platelet markers CD41, CD42b, CD62P and CD63 were assayed using flow cytometer. Platelet count, surface expression of platelet activation markers CD62P and CD63, hs-CRP, insulin and HOMA-IR score differed significantly between the groups. Post hoc analysis showed significantly high CD63 expression in patients with comorbid diabetes and depression compared to those having diabetes without depression. Patients with comorbid diabetes and depression have enhanced platelet hyperactivation and a pro inflammatory state which increases susceptibility to vascular complications.
Bibliografie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-13037-z