Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

Deep learning-based tools may annotate and interpret medical data more quickly, consistently, and accurately than medical doctors. However, as medical doctors are ultimately responsible for clinical decision-making, any deep learning-based prediction should be accompanied by an explanation that a hu...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports Vol. 11; no. 1; pp. 10949 - 11
Main Authors: Hicks, Steven A., Isaksen, Jonas L., Thambawita, Vajira, Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan, Grarup, Niels, Strümke, Inga, Ellervik, Christina, Olesen, Morten Salling, Hansen, Torben, Graff, Claus, Holstein-Rathlou, Niels-Henrik, Halvorsen, Pål, Maleckar, Mary M., Riegler, Michael A., Kanters, Jørgen K.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 26.05.2021
Nature Publishing Group
Nature Portfolio
Subjects:
631/114/1305
692/4019
Clinical decision making
Decision making
Deep learning
EKG
Electrocardiography
Humanities and Social Sciences
multidisciplinary
Neural networks
Science
Science (multidisciplinary)
ISSN:2045-2322, 2045-2322
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Deep learning-based tools may annotate and interpret medical data more quickly, consistently, and accurately than medical doctors. However, as medical doctors are ultimately responsible for clinical decision-making, any deep learning-based prediction should be accompanied by an explanation that a human can understand. We present an approach called electrocardiogram gradient class activation map (ECGradCAM), which is used to generate attention maps and explain the reasoning behind deep learning-based decision-making in ECG analysis. Attention maps may be used in the clinic to aid diagnosis, discover new medical knowledge, and identify novel features and characteristics of medical tests. In this paper, we showcase how ECGradCAM attention maps can unmask how a novel deep learning model measures both amplitudes and intervals in 12-lead electrocardiograms, and we show an example of how attention maps may be used to develop novel ECG features.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90285-5