Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study

Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammator...

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Veröffentlicht in:Scientific reports Jg. 11; H. 1; S. 13350 - 7
Hauptverfasser: Lombardi, Andrea, Duiella, Silvia, Li Piani, Letizia, Comelli, Agnese, Ceriotti, Ferruccio, Oggioni, Massimo, Muscatello, Antonio, Bandera, Alessandra, Gori, Andrea, Ferrazzi, Enrico
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 25.06.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
692/53/2423
692/699/255/2514
Biomarkers
C-reactive protein
Cohort analysis
Coronaviruses
COVID-19
Ferritin
Humanities and Social Sciences
Inflammation
Leukocytes (neutrophilic)
Lymphocytes
multidisciplinary
Neutrophils
Obstetrics
Oxygen
Pandemics
Science
Science (multidisciplinary)
Supplements
Viral diseases
ISSN:2045-2322, 2045-2322
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Zusammenfassung:Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammatory biomarkers and hemocytometry variables in a cohort of obstetric patients hospitalized with COVID-19 and we have correlated the values at admission with the need of oxygen supplementation during the hospitalization. Overall, among 62 (27.3%) pregnant women and 165 (72.7%) postpartum women, 21 (9.2%) patients received oxygen supplementation and 2 (0.9%) required admission to intensive care unit but none died. During hospitalization leukocytes (p < 0.001), neutrophils (p < 0.001), neutrophils to lymphocytes ratio (p < 0.001) and C reactive protein (p < 0.001) decreased significantly, whereas lymphocytes (p < 0.001), platelets (p < 0.001) and ferritin (p = 0.001) increased. Lymphocyte values at admission were correlated with oxygen need, with a 26% higher risk of oxygen supplementation for each 1000 cells decreases. Overall, in obstetric patients hospitalized with COVID-19, C reactive protein is the inflammatory biomarker that better mirrors the course of the disease whereas D-dimer or ferritin are not reliable predictors of poor outcome. Care to the need of oxygen supplementation should be reserved to patients with reduced lymphocyte values at admission.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92885-7