Risk of tuberculosis after initiation of antiretroviral therapy among persons with HIV in Europe

•The tuberculosis (TB) risk after antiretroviral treatment (ART) initiation in Europe is studied.•TB peaked within 3 months post ART (14.41/1000 PY).•TB was linked to certain baseline risk factors.•TB risk declined over time but remained above European background.•Thorough TB risk assessment essenti...

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Vydáno v:International journal of infectious diseases Ročník 147; s. 107199
Hlavní autoři: Johansen, Isik S., Roen, Ashley, Kraef, Christian, Martín-Iguacel, Raquel, Nemeth, Johannes, Fenner, Lukas, Zangerle, Robert, Llibre, Josep M., Miller, Robert F., Suarez, Isabelle, de Wit, Stephane, Wit, Ferdinand, Mussini, Christina, Saracino, Annalisa, Canetti, Diana, Volny-Anne, Alain, Jaschinski, Nadine, Neesgaard, Bastian, Ryom, Lene, Peters, Lars, Garges, Harmony P., Rooney, James F., Podlekareva, Daria, Mocroft, Amanda, Kirk, Ole
Médium: Journal Article
Jazyk:angličtina
Vydáno: Canada Elsevier Ltd 01.10.2024
Elsevier
Témata:
Adult
AIDS
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
CD4 Lymphocyte Count
Cohort Studies
Europe - epidemiology
Female
HIV Infections - drug therapy
HIV Infections - epidemiology
Humans
Incidence
Male
Middle Aged
Risk Factors
TB/HIV
Tuberculosis - epidemiology
Europe
AIDS
ART
TB/HIV
incidence
ISSN:1201-9712, 1878-3511, 1878-3511
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Shrnutí:•The tuberculosis (TB) risk after antiretroviral treatment (ART) initiation in Europe is studied.•TB peaked within 3 months post ART (14.41/1000 PY).•TB was linked to certain baseline risk factors.•TB risk declined over time but remained above European background.•Thorough TB risk assessment essential at ART onset. Tuberculosis (TB) risk after initiation of antiretroviral treatment (ART) is not well described in a European setting, with an average TB incidence of 25/105 in the background population. We included all adult persons with HIV starting ART in the RESPOND cohort between 2012 and 2020. TB incidence rates (IR) were assessed for consecutive time intervals post-ART initiation. Risk factors for TB within 6 months from ART initiation were evaluated using Poisson regression models. Among 8441 persons with HIV, who started ART, 66 developed TB during 34,239 person-years of follow-up (PYFU), corresponding to 1.87/1000 PYFU (95% confidence interval [CI]: 1.47-2.37). TB IR was highest in the first 3 months after ART initiation (14.41/1000 PY (95%CI 10.08-20.61]) and declined at 3-6, 6-12, and >12 months post-ART initiation (5.89 [95%CI 3.35-10.37], 2.54 [95%CI 1.36-4.73] and 0.51 [95%CI 0.30-0.86]), respectively. Independent risk factors for TB within the first 6 months after ART initiation included follow-up in Northern or Eastern Europe region, African origin, baseline CD4 count <200 cells/mm3, HIV RNA >100,000 copies/mL, injecting drug use and heterosexual transmission. TB IR was highest in the first 3 months post-ART initiation and was associated with baseline risk factors, highlighting the importance of thorough TB risk assessment at ART initiation.
Bibliografie:ObjectType-Article-1
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ISSN:1201-9712
1878-3511
1878-3511
DOI:10.1016/j.ijid.2024.107199