Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

BACE is an enzyme necessary for the generation of neurotoxic amyloid-β in Alzheimer's disease. Claes Wahlestedt and his colleagues identify a noncoding RNA that is upregulated in the brains of individuals with Alzheimer's disase. This noncoding RNA increases expression of BACE, driving amy...

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Bibliographic Details
Published in:	Nature medicine Vol. 14; no. 7; pp. 723 - 730
Main Authors:	Faghihi, Mohammad Ali, Modarresi, Farzaneh, Khalil, Ahmad M, Wood, Douglas E, Sahagan, Barbara G, Morgan, Todd E, Finch, Caleb E, St. Laurent III, Georges, Kenny, Paul J, Wahlestedt, Claes
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.07.2008 Nature Publishing Group
Subjects:	Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-protein Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals Antisense RNA Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Development and progression Feedback, Physiological Gene expression Gene Expression Regulation Genetic aspects Health aspects Humans Infectious Diseases Male Metabolic Diseases Mice Mice, Transgenic Middle Aged Models, Genetic Molecular Medicine Neuroblastoma - pathology Neurosciences Peptide Fragments - metabolism Physiological aspects Protein Processing, Post-Translational RNA, Messenger - metabolism RNA, Small Interfering - pharmacology RNA, Untranslated - analysis RNA, Untranslated - metabolism Transcription, Genetic Transfection United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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