Remitting infections due to community-acquired Panton–Valentine leukocidin-producing Staphylococcus aureus in the Milan area

One of the most important Staphylococcus aureus virulence factors is Panton–Valentine leukocidin (PVL). We describe an outbreak of recurrent cutaneous PVL infections in different members of three family clusters. Molecular investigations were performed to confirm the presence of the mecA and PVL gen...

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Veröffentlicht in:Journal of infection and public health Jg. 11; H. 2; S. 255 - 259
Hauptverfasser: Rimoldi, Sara G., Pagani, Cristina, Longhi, Erika, Cristo, Valentina D., Gregorio, Annamaria D., Mancon, Alessandro, Zerbi, Pietro, Gervasoni, Cristina, Gismondo, Maria R., Riva, Agostino
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.03.2018
Elsevier
Schlagworte:
Abscess - microbiology
Adult
Bacterial Toxins - biosynthesis
Child
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-acquired methicillin-resistant Staphylococcus aureus
Exotoxins - biosynthesis
Female
Humans
Infant
Leukocidins - biosynthesis
Male
Microbial Sensitivity Tests
Multilocus Sequence Typing
Panton–Valentine leukocidin
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus aureus - isolation & purification
Staphylococcus aureus - physiology
Virulence Factors
Panton–Valentine leukocidin
Community-acquired methicillin-resistant Staphylococcus aureus
ISSN:1876-0341, 1876-035X, 1876-035X
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Zusammenfassung:One of the most important Staphylococcus aureus virulence factors is Panton–Valentine leukocidin (PVL). We describe an outbreak of recurrent cutaneous PVL infections in different members of three family clusters. Molecular investigations were performed to confirm the presence of the mecA and PVL genes and to assign the SCCmec type, sequence type (ST) and clonal relatedness. A strain of PVL-producing methicillin-resistant S. aureus (MRSA) was responsible for infection in two related families (A and B), and a third family (C) was infected with PVL-producing methicillin-sensitive S. aureus (MSSA). Molecular investigations revealed the same clone of community-acquired (CA)-MRSA, PVL positive ST8, and SCCmec IV in families A and B and CA-MSSA PVL positive ST15 in family C. S. aureus PVL may give rise to recurrent uncontrolled infections that are difficult to eradicate, and close family contacts are at high risk for transmission.
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1876-0341
1876-035X
1876-035X
DOI:10.1016/j.jiph.2017.08.012