Tuberculin skin test – Outdated or still useful for Latent TB infection screening?
•Tuberculin skin test (TST) is over a century old but it continues to be used widely.•When IGRAs were introduced it was anticipated that they would rapidly replace TST.•Neither TST nor IGRAs have a high accuracy for predicting active TB.•Latest WHO recommendations are that either TST or IGRA can be...
Uloženo v:
| Vydáno v: | International journal of infectious diseases Ročník 80; s. S20 - S22 |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Canada
Elsevier Ltd
01.03.2019
Elsevier |
| Témata: | |
| ISSN: | 1201-9712, 1878-3511, 1878-3511 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | •Tuberculin skin test (TST) is over a century old but it continues to be used widely.•When IGRAs were introduced it was anticipated that they would rapidly replace TST.•Neither TST nor IGRAs have a high accuracy for predicting active TB.•Latest WHO recommendations are that either TST or IGRA can be used to test for LTBI.•TST will be clinically useful until more accurate tests become available.
To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings.
We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases “L. Spallanzani” as indirect indicator of usage of both tests under actual programmatic conditions.
Current national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute “L. Spallanzani” showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%).
Neither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results. |
|---|---|
| AbstractList | •Tuberculin skin test (TST) is over a century old but it continues to be used widely.•When IGRAs were introduced it was anticipated that they would rapidly replace TST.•Neither TST nor IGRAs have a high accuracy for predicting active TB.•Latest WHO recommendations are that either TST or IGRA can be used to test for LTBI.•TST will be clinically useful until more accurate tests become available.
To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings.
We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases “L. Spallanzani” as indirect indicator of usage of both tests under actual programmatic conditions.
Current national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute “L. Spallanzani” showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%).
Neither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results. Objective: To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings. Methods: We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases “L. Spallanzani” as indirect indicator of usage of both tests under actual programmatic conditions. Results: Current national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute “L. Spallanzani” showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%). Conclusion: Neither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results. Keywords: Tuberculin skin test, TST, Interferon-γ release assays, IGRA, Tuberculosis, Quantiferon, TB, Latent TB, LTBI To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings.OBJECTIVETo make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings.We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases "L. Spallanzani" as indirect indicator of usage of both tests under actual programmatic conditions.METHODSWe reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases "L. Spallanzani" as indirect indicator of usage of both tests under actual programmatic conditions.Current national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute "L. Spallanzani" showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%).RESULTSCurrent national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute "L. Spallanzani" showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%).Neither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results.CONCLUSIONNeither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results. To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings. We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases "L. Spallanzani" as indirect indicator of usage of both tests under actual programmatic conditions. Current national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute "L. Spallanzani" showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%). Neither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results. |
| Author | Lauria, Francesco Nicola Palmieri, Fabrizio Ippolito, Giuseppe Gualano, Gina Mfinanga, Sayoki Mwaba, Peter Chakaya, Jeremiah Mencarini, Paola Zumla, Alimuddin |
| Author_xml | – sequence: 1 givenname: Gina orcidid: 0000-0001-6149-0005 surname: Gualano fullname: Gualano, Gina email: gina.gualano@inmi.it organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy – sequence: 2 givenname: Paola surname: Mencarini fullname: Mencarini, Paola email: paola.mencarini@inmi.it organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy – sequence: 3 givenname: Francesco Nicola surname: Lauria fullname: Lauria, Francesco Nicola email: francesco.lauria@inmi.it organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy – sequence: 4 givenname: Fabrizio surname: Palmieri fullname: Palmieri, Fabrizio email: fabrizio.palmieri@inmi.it organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy – sequence: 5 givenname: Sayoki surname: Mfinanga fullname: Mfinanga, Sayoki email: gsmfinanga@yahoo.com organization: National Institute for Medical Research Muhimbili, Dar es Salaam, Tanzania – sequence: 6 givenname: Peter surname: Mwaba fullname: Mwaba, Peter email: pbmwaba2000@gmail.com organization: UNZA-UCLMS Project, and Lusaka Apex University Medical School, Lusaka, Zambia – sequence: 7 givenname: Jeremiah surname: Chakaya fullname: Chakaya, Jeremiah email: chakaya.jm@gmail.com organization: International Union Against TB and Lung Diseases, Paris, France – sequence: 8 givenname: Alimuddin surname: Zumla fullname: Zumla, Alimuddin email: a.i.zumla@ucl.ac.uk organization: Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, & NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK – sequence: 9 givenname: Giuseppe orcidid: 0000-0002-1076-2979 surname: Ippolito fullname: Ippolito, Giuseppe email: giuseppe.ippolito@inmi.it organization: National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30738186$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFks1u1TAQhS1URH_gBVigLNkkeBzHcRASgoqfSlfq5rK2HHtcOfVNiu0gdcc78IY8Cb7c0kUXZWNbM-ebkc7xKTmalxkJeQm0AQrizdT4yduGURgaCg3l8gk5AdnLuu0Ajsq7tOqhB3ZMTlOaKKVcCPmMHLe0byVIcUK223XEaNbg5ypdlyNjytXvn7-qyzVbndFWS6xS9iFUa0K3hsqVwqZ05lxtP1Z-dmiyXwpuIuLs56v3z8lTp0PCF3f3Gfn2-dP2_Gu9ufxycf5hU5sO-lxz2XWdNcAkADejHfuhdVoatD3V1HZCg2UdDpwJENSx0fF-0ExSXnQdZ-0ZuTjMtYue1E30Ox1v1aK9-ltY4pXSMXsTUA0ah4Ex4YzuueZOt0yggZYiN5yPQ5n1-jDrJi7f12KC2vlkMAQ947ImxYpdAiTraJG-upOu4w7t_eJ_rhYBOwhMXFKK6O4lQNU-OjWpfXRqH52ioEp0BZIPIOOz3jubo_bhcfTdAcVi9g-PUSXjcS5G-ljCKW74x_G3D3BTvoM3Olzj7f_gP6Rexwc |
| CitedBy_id | crossref_primary_10_1159_000514875 crossref_primary_10_1038_s41598_024_68452_1 crossref_primary_10_1136_bmjopen_2024_097505 crossref_primary_10_4103_ijmy_ijmy_176_23 crossref_primary_10_3389_fmicb_2023_1225438 crossref_primary_10_1007_s15010_022_01789_9 crossref_primary_10_3390_ijerph192013529 crossref_primary_10_1016_j_ijid_2019_02_024 crossref_primary_10_1155_2022_2090560 crossref_primary_10_3390_antiox10020177 crossref_primary_10_1016_j_tube_2024_102537 crossref_primary_10_1186_s40779_023_00490_8 crossref_primary_10_3892_etm_2019_7791 crossref_primary_10_1186_s13756_024_01419_z crossref_primary_10_4103_ecdt_ecdt_45_24 crossref_primary_10_4103_ijmy_ijmy_112_22 crossref_primary_10_1038_s41598_025_91520_z crossref_primary_10_1016_j_cmi_2024_10_016 crossref_primary_10_1108_IJOPH_09_2020_0067 crossref_primary_10_1007_s00431_025_05972_6 crossref_primary_10_1016_j_ejr_2024_11_003 crossref_primary_10_1007_s10854_021_07538_2 crossref_primary_10_1007_s12098_024_05024_1 crossref_primary_10_1183_16000617_0044_2022 crossref_primary_10_1016_j_tube_2022_102256 crossref_primary_10_3390_diseases12090202 crossref_primary_10_1080_14787210_2019_1625770 crossref_primary_10_1186_s13690_025_01504_8 crossref_primary_10_1136_bmjgh_2023_012297 crossref_primary_10_4081_monaldi_2025_3258 crossref_primary_10_1016_j_ijid_2020_09_020 crossref_primary_10_3390_vaccines10111892 crossref_primary_10_1016_j_ijid_2019_12_012 crossref_primary_10_1186_s12879_021_06141_4 |
| Cites_doi | 10.1001/jama.2012.7511 10.1183/09031936.00114810 10.1111/j.1469-0691.2011.03555.x 10.7326/0003-4819-149-3-200808050-00241 10.1177/003335491613100214 10.1016/S1473-3099(11)70210-9 10.4046/trd.2017.0072 10.1016/S1473-3099(18)30355-4 |
| ContentType | Journal Article |
| Copyright | 2019 Copyright © 2019. Published by Elsevier Ltd. |
| Copyright_xml | – notice: 2019 – notice: Copyright © 2019. Published by Elsevier Ltd. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 DOA |
| DOI | 10.1016/j.ijid.2019.01.048 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Public Health |
| EISSN | 1878-3511 |
| EndPage | S22 |
| ExternalDocumentID | oai_doaj_org_article_9ae99226fca74a4fa326ec130e4c44b9 30738186 10_1016_j_ijid_2019_01_048 S120197121930061X |
| Genre | Journal Article |
| GroupedDBID | --- --K .1- .FO .~1 0R~ 1B1 1P~ 1~. 1~5 29J 3O- 4.4 457 4G. 53G 5GY 5VS 7-5 71M 7X7 88E 8C1 8FI 8FJ 8FQ 8R4 8R5 AAEDW AAFWJ AAIKJ AALRI AAQFI AAQXK AARKO AAXUO AAYWO ABBQC ABFRF ABMAC ABUWG ABWVN ACGFO ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEFWE AEKER AENEX AEUPX AEVXI AEXQZ AFJKZ AFKRA AFPKN AFPUW AFRHN AFTJW AGEKW AGHFR AGQPQ AGYEJ AHMBA AIGII AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BAWUL BCNDV BENPR BPHCQ BR6 BVXVI CCPQU CS3 DIK DU5 DWQXO E3Z EBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FNPLU FYUFA G-Q GBLVA GROUPED_DOAJ GX1 HMCUK HVGLF HZ~ IHE IXB J1W KQ8 M1P M3C M3G M41 MO0 N9A O-L O9- OD- OK1 OO. OZT P-8 P-9 P2P PC. PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO Q2X Q38 QTD R2- ROL RPZ RWL RXW SDF SDG SEL SES SEW SSZ TAE UKHRP UNMZH Z5R ~HD 0SF 3V. 6I. AACTN AAFTH ABVKL AFCTW NCXOZ RIG 9DU AAYXX AFFHD CITATION ALIPV NPM 7X8 |
| ID | FETCH-LOGICAL-c517t-48555dc128114cbdb793fa8ced70a0d56a1d25e9426160f2bf479a280493f5423 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 37 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000460660800006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1201-9712 1878-3511 |
| IngestDate | Fri Oct 03 12:40:53 EDT 2025 Sat Sep 27 17:19:54 EDT 2025 Wed Feb 19 02:33:47 EST 2025 Tue Nov 18 19:37:04 EST 2025 Sat Nov 29 06:40:53 EST 2025 Fri Feb 23 02:28:05 EST 2024 Tue Oct 14 19:35:16 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Latent TB Tuberculosis TST Quantiferon Tuberculin skin test Interferon-γ release assays LTBI TB IGRA |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2019. Published by Elsevier Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c517t-48555dc128114cbdb793fa8ced70a0d56a1d25e9426160f2bf479a280493f5423 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0001-6149-0005 0000-0002-1076-2979 |
| OpenAccessLink | https://doaj.org/article/9ae99226fca74a4fa326ec130e4c44b9 |
| PMID | 30738186 |
| PQID | 2186618250 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_9ae99226fca74a4fa326ec130e4c44b9 proquest_miscellaneous_2186618250 pubmed_primary_30738186 crossref_primary_10_1016_j_ijid_2019_01_048 crossref_citationtrail_10_1016_j_ijid_2019_01_048 elsevier_sciencedirect_doi_10_1016_j_ijid_2019_01_048 elsevier_clinicalkey_doi_10_1016_j_ijid_2019_01_048 |
| PublicationCentury | 2000 |
| PublicationDate | March 2019 2019-03-00 2019-Mar 20190301 2019-03-01 |
| PublicationDateYYYYMMDD | 2019-03-01 |
| PublicationDate_xml | – month: 03 year: 2019 text: March 2019 |
| PublicationDecade | 2010 |
| PublicationPlace | Canada |
| PublicationPlace_xml | – name: Canada |
| PublicationTitle | International journal of infectious diseases |
| PublicationTitleAlternate | Int J Infect Dis |
| PublicationYear | 2019 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | National Institute for Health and Clinical Excellence. NICE guidelines: Tuberculosis; 13 January (2016). Available at World Health Organization (bib0065) 2018 Abubakar, Drobniewski, Southern (bib0005) 2018; 18 Denkinger, Dheda, Pai (bib0010) 2011; 17 LoBue, Castro (bib0020) 2012; 308 [Accessed November 25, 2018]. European Centre for Disease Prevention and Control (bib0015) 2011 Wilson, Miller, Stimpson (bib0060) 2016; 131 Overton, Varma, Post (bib0035) 2018; 81 Mazurek, Jereb, Vernon, LoBue, Goldberg, Castro (bib0025) 2010; 59 Rangaka, Wilkinson, Glynn (bib0045) 2012; 12 Sester, Sotgiu, Lange (bib0050) 2011; 37 Pai, Zwerling, Menzies (bib0040) 2008; 149 Vesenbeckh, Schönfeld, Mauch (bib0055) 2012; 2012 Mazurek (10.1016/j.ijid.2019.01.048_bib0025) 2010; 59 Abubakar (10.1016/j.ijid.2019.01.048_bib0005) 2018; 18 Wilson (10.1016/j.ijid.2019.01.048_bib0060) 2016; 131 Overton (10.1016/j.ijid.2019.01.048_bib0035) 2018; 81 LoBue (10.1016/j.ijid.2019.01.048_bib0020) 2012; 308 Rangaka (10.1016/j.ijid.2019.01.048_bib0045) 2012; 12 European Centre for Disease Prevention and Control (10.1016/j.ijid.2019.01.048_bib0015) 2011 Pai (10.1016/j.ijid.2019.01.048_bib0040) 2008; 149 World Health Organization (10.1016/j.ijid.2019.01.048_bib0065) 2018 Denkinger (10.1016/j.ijid.2019.01.048_bib0010) 2011; 17 10.1016/j.ijid.2019.01.048_bib0030 Sester (10.1016/j.ijid.2019.01.048_bib0050) 2011; 37 Vesenbeckh (10.1016/j.ijid.2019.01.048_bib0055) 2012; 2012 |
| References_xml | – volume: 17 start-page: 806 year: 2011 end-page: 814 ident: bib0010 article-title: Guidelines on interferon-γ release assays for tuberculosis infection: concordance, discordance or confusion? publication-title: Clin Microbiol Infect – reference: National Institute for Health and Clinical Excellence. NICE guidelines: Tuberculosis; 13 January (2016). Available at – reference: . [Accessed November 25, 2018]. – volume: 81 start-page: 59 year: 2018 end-page: 72 ident: bib0035 article-title: Comparison of interferon-γ release assays and the tuberculin skin test for diagnosis of tuberculosis in human immunodeficiency virus: a systematic review publication-title: Tuberc Respir Dis – volume: 18 start-page: 1077 year: 2018 end-page: 1087 ident: bib0005 article-title: Prognostic value of interferon-γ gamma release assays and tuberculin skin test in predicting the development of active tuberculosis: the UK PREDICT tuberculosis cohort study publication-title: Lancet Infect Dis – volume: 149 start-page: 177 year: 2008 end-page: 184 ident: bib0040 article-title: Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update publication-title: Ann Intern Med – volume: 131 start-page: 303 year: 2016 end-page: 310 ident: bib0060 article-title: infection, immigration status, and diagnostic discordance: a comparison of tuberculin skin test and QuantiFERON-TB gold in-tube test among immigrants to the U.S publication-title: Public Health Rep – volume: 308 start-page: 241 year: 2012 end-page: 242 ident: bib0020 article-title: Is it time to replace the Tuberculin skin test with a blood test publication-title: JAMA – volume: 59 start-page: 1 year: 2010 end-page: 25 ident: bib0025 article-title: IGRA Expert Committee. Centers for Disease Control and Prevention (CDC). Updated guidelines for using Interferon Gamma Release Assays to detect publication-title: MMWR Recomm Rep – year: 2011 ident: bib0015 article-title: Use of interferon-gamma release assays in support of TB diagnosis – volume: 2012 start-page: 768723 year: 2012 ident: bib0055 article-title: The use of interferon gamma release assays in the diagnosis of active tuberculosis publication-title: Tuberc Res Treat – volume: 37 start-page: 100 year: 2011 end-page: 111 ident: bib0050 article-title: Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis publication-title: Eur Respir J – year: 2018 ident: bib0065 article-title: Latent tuberculosis infection: updated and consolidated guidelines for programmatic management – volume: 12 start-page: 45 year: 2012 end-page: 55 ident: bib0045 article-title: Predictive value of interferon-release assays for incident active tuberculosis: a systematic review and meta-analysis publication-title: Lancet Infect Dis – year: 2018 ident: 10.1016/j.ijid.2019.01.048_bib0065 – volume: 308 start-page: 241 year: 2012 ident: 10.1016/j.ijid.2019.01.048_bib0020 article-title: Is it time to replace the Tuberculin skin test with a blood test publication-title: JAMA doi: 10.1001/jama.2012.7511 – volume: 37 start-page: 100 year: 2011 ident: 10.1016/j.ijid.2019.01.048_bib0050 article-title: Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis publication-title: Eur Respir J doi: 10.1183/09031936.00114810 – volume: 2012 start-page: 768723 year: 2012 ident: 10.1016/j.ijid.2019.01.048_bib0055 article-title: The use of interferon gamma release assays in the diagnosis of active tuberculosis publication-title: Tuberc Res Treat – volume: 17 start-page: 806 year: 2011 ident: 10.1016/j.ijid.2019.01.048_bib0010 article-title: Guidelines on interferon-γ release assays for tuberculosis infection: concordance, discordance or confusion? publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2011.03555.x – volume: 149 start-page: 177 year: 2008 ident: 10.1016/j.ijid.2019.01.048_bib0040 article-title: Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update publication-title: Ann Intern Med doi: 10.7326/0003-4819-149-3-200808050-00241 – volume: 131 start-page: 303 year: 2016 ident: 10.1016/j.ijid.2019.01.048_bib0060 article-title: Mycobacterium Tuberculosis infection, immigration status, and diagnostic discordance: a comparison of tuberculin skin test and QuantiFERON-TB gold in-tube test among immigrants to the U.S publication-title: Public Health Rep doi: 10.1177/003335491613100214 – volume: 12 start-page: 45 year: 2012 ident: 10.1016/j.ijid.2019.01.048_bib0045 article-title: Predictive value of interferon-release assays for incident active tuberculosis: a systematic review and meta-analysis publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(11)70210-9 – volume: 81 start-page: 59 year: 2018 ident: 10.1016/j.ijid.2019.01.048_bib0035 article-title: Comparison of interferon-γ release assays and the tuberculin skin test for diagnosis of tuberculosis in human immunodeficiency virus: a systematic review publication-title: Tuberc Respir Dis doi: 10.4046/trd.2017.0072 – volume: 59 start-page: 1 year: 2010 ident: 10.1016/j.ijid.2019.01.048_bib0025 article-title: IGRA Expert Committee. Centers for Disease Control and Prevention (CDC). Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection-United States, 2010 publication-title: MMWR Recomm Rep – volume: 18 start-page: 1077 year: 2018 ident: 10.1016/j.ijid.2019.01.048_bib0005 article-title: Prognostic value of interferon-γ gamma release assays and tuberculin skin test in predicting the development of active tuberculosis: the UK PREDICT tuberculosis cohort study publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(18)30355-4 – year: 2011 ident: 10.1016/j.ijid.2019.01.048_bib0015 – ident: 10.1016/j.ijid.2019.01.048_bib0030 |
| SSID | ssj0004668 |
| Score | 2.3883233 |
| SecondaryResourceType | review_article |
| Snippet | •Tuberculin skin test (TST) is over a century old but it continues to be used widely.•When IGRAs were introduced it was anticipated that they would rapidly... To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB... Objective: To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | S20 |
| SubjectTerms | IGRA Interferon-γ release assays Latent TB LTBI Quantiferon TST Tuberculin skin test Tuberculosis |
| Title | Tuberculin skin test – Outdated or still useful for Latent TB infection screening? |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S120197121930061X https://dx.doi.org/10.1016/j.ijid.2019.01.048 https://www.ncbi.nlm.nih.gov/pubmed/30738186 https://www.proquest.com/docview/2186618250 https://doaj.org/article/9ae99226fca74a4fa326ec130e4c44b9 |
| Volume | 80 |
| WOSCitedRecordID | wos000460660800006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1878-3511 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004668 issn: 1201-9712 databaseCode: DOA dateStart: 19960101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BhRASQlBey6MyEjcUESdOHJ8QRVQcSuGwoL1ZfkpbVlm0m3DmP_AP-SXMxElUDrQXLjkkdh7jseebeOYbgJeNcWgHLHon0dfooNgys1Y1med5tD4vTTNEW3w9lWdnzWqlPl8o9UUxYYkeOAnuNZFHK8QI0RkpjIgG8UZwuPIG4YSwQ-peLtXkTM0ZkSkJDs1bpiQvxnSZFNm1Pl8TRyhXA2EnVf65YJIG5v6_LNO_kOdggU7uwp0ROrK36ZXvwbXQHsLNj-Pm-CHcTr_gWMosug_LZW_DzlGoOdt_wwOiyo79_vmLfeo7cvQ92-4YTvHNhvX7EPsNQwTLTvFK27HlMZsCtbC7o_ActHJvHsCXk_fLdx-ysYhC5iouu4zIXyrvaMOMC2e9xQkZTeOCl7nJfVUb7osqKHKl6jwWNgqpTNGg51DGCsHWQzhot214DAy9nxiNd6YUUgRjcGmsFS9cDEIG5YoF8EmO2o0M41ToYqOnULJzTbLXJHudc42yX8Cruc_3xK9xaetjGp65JXFjDydQY_SoMfoqjVlAOQ2untJPccHEG60vfXQ19xrBSQIdV_Z7MemPxplL2zGmDdt-r6kaWI3uXZUv4FFSrPnDaOUlrsEn_-ODn8IteqEUOfcMDrpdH57DDfejW-93R3BdrpqjYfr8ATolG_k |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tuberculin+skin+test+%E2%80%93+Outdated+or+still+useful+for+Latent+TB+infection+screening%3F&rft.jtitle=International+journal+of+infectious+diseases&rft.au=Gina+Gualano&rft.au=Paola+Mencarini&rft.au=Francesco+Nicola+Lauria&rft.au=Fabrizio+Palmieri&rft.date=2019-03-01&rft.pub=Elsevier&rft.issn=1201-9712&rft.volume=80&rft.spage=S20&rft.epage=S22&rft_id=info:doi/10.1016%2Fj.ijid.2019.01.048&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_9ae99226fca74a4fa326ec130e4c44b9 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1201-9712&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1201-9712&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1201-9712&client=summon |