Validation of proton dose calculation on scatter corrected 4D cone beam computed tomography using a porcine lung phantom
Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while i...
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| Vydáno v: | Physics in medicine & biology Ročník 66; číslo 17 |
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IOP Publishing
30.08.2021
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| ISSN: | 1361-6560, 1361-6560 |
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| Abstract | Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while in-room 4D cone beam computed tomography (4DCBCT) suffers from image quality limitations stemming mostly from scatter detection. This study investigated the feasibility of using virtual 4D computed tomography (4DvCT) as a prior for a phase-per-phase scatter correction algorithm yielding a 4D scatter corrected cone beam computed tomography image (4DCBCTcor), which can be used for proton dose calculation. 4DCT and 4DCBCT scans of a porcine lung phantom, which generated reproducible ventilation, were acquired with matching breathing patterns. Diffeomorphic Morphons, a deformable image registration algorithm, was used to register the mid-position 4DCT to the mid-position 4DCBCT and yield a 4DvCT. The 4DCBCT was reconstructed using motion-aware reconstruction based on spatial and temporal regularization (MA-ROOSTER). Successively for each phase, digitally reconstructed radiographs of the 4DvCT, simulated without scatter, were exploited to correct scatter in the corresponding CBCT projections. The 4DCBCTcorwas then reconstructed with MA-ROOSTER using the corrected CBCT projections and the same settings and deformation vector fields as those already used for reconstructing the 4DCBCT. The 4DCBCTcorand the 4DvCT were evaluated phase-by-phase, performing proton dose calculations and comparison to those of a ground truth 4DCT by means of dose-volume-histograms (DVH) and gamma pass-rates (PR). For accumulated doses, DVH parameters deviated by at most 1.7% in the 4DvCT and 2.0% in the 4DCBCTcorcase. The gamma PR for a (2%, 2 mm) criterion with 10% threshold were at least 93.2% (4DvCT) and 94.2% (4DCBCTcor), respectively. The 4DCBCTcortechnique enabled accurate proton dose calculation, which indicates the potential for applicability to clinical 4DCBCT scans.Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while in-room 4D cone beam computed tomography (4DCBCT) suffers from image quality limitations stemming mostly from scatter detection. This study investigated the feasibility of using virtual 4D computed tomography (4DvCT) as a prior for a phase-per-phase scatter correction algorithm yielding a 4D scatter corrected cone beam computed tomography image (4DCBCTcor), which can be used for proton dose calculation. 4DCT and 4DCBCT scans of a porcine lung phantom, which generated reproducible ventilation, were acquired with matching breathing patterns. Diffeomorphic Morphons, a deformable image registration algorithm, was used to register the mid-position 4DCT to the mid-position 4DCBCT and yield a 4DvCT. The 4DCBCT was reconstructed using motion-aware reconstruction based on spatial and temporal regularization (MA-ROOSTER). Successively for each phase, digitally reconstructed radiographs of the 4DvCT, simulated without scatter, were exploited to correct scatter in the corresponding CBCT projections. The 4DCBCTcorwas then reconstructed with MA-ROOSTER using the corrected CBCT projections and the same settings and deformation vector fields as those already used for reconstructing the 4DCBCT. The 4DCBCTcorand the 4DvCT were evaluated phase-by-phase, performing proton dose calculations and comparison to those of a ground truth 4DCT by means of dose-volume-histograms (DVH) and gamma pass-rates (PR). For accumulated doses, DVH parameters deviated by at most 1.7% in the 4DvCT and 2.0% in the 4DCBCTcorcase. The gamma PR for a (2%, 2 mm) criterion with 10% threshold were at least 93.2% (4DvCT) and 94.2% (4DCBCTcor), respectively. The 4DCBCTcortechnique enabled accurate proton dose calculation, which indicates the potential for applicability to clinical 4DCBCT scans. |
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| AbstractList | Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while in-room 4D cone beam computed tomography (4DCBCT) suffers from image quality limitations stemming mostly from scatter detection. This study investigated the feasibility of using virtual 4D computed tomography (4DvCT) as a prior for a phase-per-phase scatter correction algorithm yielding a 4D scatter corrected cone beam computed tomography image (4DCBCTcor), which can be used for proton dose calculation. 4DCT and 4DCBCT scans of a porcine lung phantom, which generated reproducible ventilation, were acquired with matching breathing patterns. Diffeomorphic Morphons, a deformable image registration algorithm, was used to register the mid-position 4DCT to the mid-position 4DCBCT and yield a 4DvCT. The 4DCBCT was reconstructed using motion-aware reconstruction based on spatial and temporal regularization (MA-ROOSTER). Successively for each phase, digitally reconstructed radiographs of the 4DvCT, simulated without scatter, were exploited to correct scatter in the corresponding CBCT projections. The 4DCBCTcorwas then reconstructed with MA-ROOSTER using the corrected CBCT projections and the same settings and deformation vector fields as those already used for reconstructing the 4DCBCT. The 4DCBCTcorand the 4DvCT were evaluated phase-by-phase, performing proton dose calculations and comparison to those of a ground truth 4DCT by means of dose-volume-histograms (DVH) and gamma pass-rates (PR). For accumulated doses, DVH parameters deviated by at most 1.7% in the 4DvCT and 2.0% in the 4DCBCTcorcase. The gamma PR for a (2%, 2 mm) criterion with 10% threshold were at least 93.2% (4DvCT) and 94.2% (4DCBCTcor), respectively. The 4DCBCTcortechnique enabled accurate proton dose calculation, which indicates the potential for applicability to clinical 4DCBCT scans.Proton therapy treatment for lungs remains challenging as images enabling the detection of inter- and intra-fractional motion, which could be used for proton dose adaptation, are not readily available. 4D computed tomography (4DCT) provides high image quality but is rarely available in-room, while in-room 4D cone beam computed tomography (4DCBCT) suffers from image quality limitations stemming mostly from scatter detection. This study investigated the feasibility of using virtual 4D computed tomography (4DvCT) as a prior for a phase-per-phase scatter correction algorithm yielding a 4D scatter corrected cone beam computed tomography image (4DCBCTcor), which can be used for proton dose calculation. 4DCT and 4DCBCT scans of a porcine lung phantom, which generated reproducible ventilation, were acquired with matching breathing patterns. Diffeomorphic Morphons, a deformable image registration algorithm, was used to register the mid-position 4DCT to the mid-position 4DCBCT and yield a 4DvCT. The 4DCBCT was reconstructed using motion-aware reconstruction based on spatial and temporal regularization (MA-ROOSTER). Successively for each phase, digitally reconstructed radiographs of the 4DvCT, simulated without scatter, were exploited to correct scatter in the corresponding CBCT projections. The 4DCBCTcorwas then reconstructed with MA-ROOSTER using the corrected CBCT projections and the same settings and deformation vector fields as those already used for reconstructing the 4DCBCT. The 4DCBCTcorand the 4DvCT were evaluated phase-by-phase, performing proton dose calculations and comparison to those of a ground truth 4DCT by means of dose-volume-histograms (DVH) and gamma pass-rates (PR). For accumulated doses, DVH parameters deviated by at most 1.7% in the 4DvCT and 2.0% in the 4DCBCTcorcase. The gamma PR for a (2%, 2 mm) criterion with 10% threshold were at least 93.2% (4DvCT) and 94.2% (4DCBCTcor), respectively. The 4DCBCTcortechnique enabled accurate proton dose calculation, which indicates the potential for applicability to clinical 4DCBCT scans. |
| Author | Janssens, Guillaume Rit, Simon Kurz, Christopher Rabe, Moritz Landry, Guillaume Parodi, Katia Belka, Claus Schmitz, Henning Dinkel, Julien Kamp, Florian Bondesson, David |
| Author_xml | – sequence: 1 givenname: Henning orcidid: 0000-0001-6143-1187 surname: Schmitz fullname: Schmitz, Henning organization: University Hospital Department of Radiation Oncology, LMU Munich, Munich, Germany – sequence: 2 givenname: Moritz orcidid: 0000-0002-7085-4066 surname: Rabe fullname: Rabe, Moritz organization: University Hospital Department of Radiation Oncology, LMU Munich, Munich, Germany – sequence: 3 givenname: Guillaume orcidid: 0000-0001-9553-6024 surname: Janssens fullname: Janssens, Guillaume organization: Ion Beam Applications SA , Louvain-la-neuve, Belgium – sequence: 4 givenname: David orcidid: 0000-0003-3112-886X surname: Bondesson fullname: Bondesson, David organization: University Hospital Department of Radiology, LMU Munich, Munich, Germany – sequence: 5 givenname: Simon surname: Rit fullname: Rit, Simon organization: Université Claude Bernard Lyon 1 Univ Lyon, INSA-Lyon, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F-69373, LYON, France – sequence: 6 givenname: Katia orcidid: 0000-0001-7779-6690 surname: Parodi fullname: Parodi, Katia organization: Ludwig-Maximilians-Universität München (LMU Munich) Department of Medical Physics, Faculty of Physics, Garching (Munich), Germany – sequence: 7 givenname: Claus surname: Belka fullname: Belka, Claus organization: Partner Site Munich German Cancer Consortium (DKTK), Munich, Germany – sequence: 8 givenname: Julien surname: Dinkel fullname: Dinkel, Julien organization: University Hospital Department of Radiology, LMU Munich, Munich, Germany – sequence: 9 givenname: Christopher surname: Kurz fullname: Kurz, Christopher organization: Ludwig-Maximilians-Universität München (LMU Munich) Department of Medical Physics, Faculty of Physics, Garching (Munich), Germany – sequence: 10 givenname: Florian surname: Kamp fullname: Kamp, Florian organization: University Hospital Cologne Department of Radiation Oncology, Cologne, Germany – sequence: 11 givenname: Guillaume orcidid: 0000-0003-1707-4068 surname: Landry fullname: Landry, Guillaume organization: Ludwig-Maximilians-Universität München (LMU Munich) Department of Medical Physics, Faculty of Physics, Garching (Munich), Germany |
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| Title | Validation of proton dose calculation on scatter corrected 4D cone beam computed tomography using a porcine lung phantom |
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