Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults

DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the E...

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Veröffentlicht in:	Nature communications Jg. 13; H. 1; S. 5269 - 11
Hauptverfasser:	Li, Xiangwei, Delerue, Thomas, Schöttker, Ben, Holleczek, Bernd, Grill, Eva, Peters, Annette, Waldenberger, Melanie, Thorand, Barbara, Brenner, Hermann
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 07.09.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	631/208/176/1988 692/308/174 692/308/53/2423 692/700/1518 Adults Aging Algorithms Deoxyribonucleic acid DNA DNA methylation Epigenetics Frailty Humanities and Social Sciences multidisciplinary Older people Performance prediction Peripheral blood Population studies Risk analysis Risk factors Science Science (multidisciplinary) Wide screen
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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