The role of lymphangiogenesis in cardiovascular diseases and heart transplantation

Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases includin...

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Veröffentlicht in:Heart failure reviews Jg. 27; H. 5; S. 1837 - 1856
1. Verfasser: Ji, Rui-Cheng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Springer US 01.09.2022
Springer Nature B.V
Schlagworte:
Arteriosclerosis
Atherosclerosis
Blood vessels
Cardiac function
Cardiology
Cardiovascular diseases
Connective tissue
Coronary artery disease
Edema
Fibrosis
Heart attacks
Heart diseases
Heart failure
Heart transplantation
Homeostasis
Hyaluronic acid
Immune response
Immunoregulation
Inflammation
Lymphatic drainage
Medicine
Medicine & Public Health
Molecular modelling
Myocardial infarction
Pathogenesis
Transplants & implants
Vascular endothelial growth factor
Wound healing
Myocardial infarction
Lymphangiogenesis
Cardiovascular diseases
VEGF-C/VEGFR-3
Heart transplantation
Atherosclerosis
ISSN:1382-4147, 1573-7322, 1573-7322
Online-Zugang:Volltext
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Zusammenfassung:Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases including atherosclerosis and myocardial infarction (MI). Although the molecular mechanisms underlying the regulation of functional lymphatics are not fully understood, the interplay between lymphangiogenesis and immune regulation has recently been explored in relation to the initiation and development of these diseases. In this field, experimental therapeutic strategies targeting lymphangiogenesis have shown promise by reducing myocardial inflammation, edema and fibrosis, and improving cardiac function. On the other hand, however, whether lymphangiogenesis is beneficial or detrimental to cardiac transplant survival remains controversial. In the light of recent evidence, cardiac lymphangiogenesis, a thriving and challenging field has been summarized and discussed, which may improve our knowledge in the pathogenesis of cardiovascular diseases and transplant biology.
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ISSN:1382-4147
1573-7322
1573-7322
DOI:10.1007/s10741-021-10188-5