The role of lymphangiogenesis in cardiovascular diseases and heart transplantation

Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases includin...

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Published in:	Heart failure reviews Vol. 27; no. 5; pp. 1837 - 1856
Main Author:	Ji, Rui-Cheng
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.09.2022 Springer Nature B.V
Subjects:	Arteriosclerosis Atherosclerosis Blood vessels Cardiac function Cardiology Cardiovascular diseases Connective tissue Coronary artery disease Edema Fibrosis Heart attacks Heart diseases Heart failure Heart transplantation Homeostasis Hyaluronic acid Immune response Immunoregulation Inflammation Lymphatic drainage Medicine Medicine & Public Health Molecular modelling Myocardial infarction Pathogenesis Transplants & implants Vascular endothelial growth factor Wound healing Myocardial infarction Lymphangiogenesis Cardiovascular diseases VEGF-C/VEGFR-3 Heart transplantation Atherosclerosis
ISSN:	1382-4147, 1573-7322, 1573-7322
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Abstract	Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases including atherosclerosis and myocardial infarction (MI). Although the molecular mechanisms underlying the regulation of functional lymphatics are not fully understood, the interplay between lymphangiogenesis and immune regulation has recently been explored in relation to the initiation and development of these diseases. In this field, experimental therapeutic strategies targeting lymphangiogenesis have shown promise by reducing myocardial inflammation, edema and fibrosis, and improving cardiac function. On the other hand, however, whether lymphangiogenesis is beneficial or detrimental to cardiac transplant survival remains controversial. In the light of recent evidence, cardiac lymphangiogenesis, a thriving and challenging field has been summarized and discussed, which may improve our knowledge in the pathogenesis of cardiovascular diseases and transplant biology.
AbstractList	Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases including atherosclerosis and myocardial infarction (MI). Although the molecular mechanisms underlying the regulation of functional lymphatics are not fully understood, the interplay between lymphangiogenesis and immune regulation has recently been explored in relation to the initiation and development of these diseases. In this field, experimental therapeutic strategies targeting lymphangiogenesis have shown promise by reducing myocardial inflammation, edema and fibrosis, and improving cardiac function. On the other hand, however, whether lymphangiogenesis is beneficial or detrimental to cardiac transplant survival remains controversial. In the light of recent evidence, cardiac lymphangiogenesis, a thriving and challenging field has been summarized and discussed, which may improve our knowledge in the pathogenesis of cardiovascular diseases and transplant biology. Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases including atherosclerosis and myocardial infarction (MI). Although the molecular mechanisms underlying the regulation of functional lymphatics are not fully understood, the interplay between lymphangiogenesis and immune regulation has recently been explored in relation to the initiation and development of these diseases. In this field, experimental therapeutic strategies targeting lymphangiogenesis have shown promise by reducing myocardial inflammation, edema and fibrosis, and improving cardiac function. On the other hand, however, whether lymphangiogenesis is beneficial or detrimental to cardiac transplant survival remains controversial. In the light of recent evidence, cardiac lymphangiogenesis, a thriving and challenging field has been summarized and discussed, which may improve our knowledge in the pathogenesis of cardiovascular diseases and transplant biology.Cardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases including atherosclerosis and myocardial infarction (MI). Although the molecular mechanisms underlying the regulation of functional lymphatics are not fully understood, the interplay between lymphangiogenesis and immune regulation has recently been explored in relation to the initiation and development of these diseases. In this field, experimental therapeutic strategies targeting lymphangiogenesis have shown promise by reducing myocardial inflammation, edema and fibrosis, and improving cardiac function. On the other hand, however, whether lymphangiogenesis is beneficial or detrimental to cardiac transplant survival remains controversial. In the light of recent evidence, cardiac lymphangiogenesis, a thriving and challenging field has been summarized and discussed, which may improve our knowledge in the pathogenesis of cardiovascular diseases and transplant biology.
Author	Ji, Rui-Cheng
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Keywords	Myocardial infarction Lymphangiogenesis Cardiovascular diseases VEGF-C/VEGFR-3 Heart transplantation Atherosclerosis
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SubjectTerms	Arteriosclerosis Atherosclerosis Blood vessels Cardiac function Cardiology Cardiovascular diseases Connective tissue Coronary artery disease Edema Fibrosis Heart attacks Heart diseases Heart failure Heart transplantation Homeostasis Hyaluronic acid Immune response Immunoregulation Inflammation Lymphatic drainage Medicine Medicine & Public Health Molecular modelling Myocardial infarction Pathogenesis Transplants & implants Vascular endothelial growth factor Wound healing
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Title	The role of lymphangiogenesis in cardiovascular diseases and heart transplantation
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