Modelling the impact of initiation delay, duration and prior PrEP on the efficacy of post‐exposure prophylaxis containing a tenofovir/emtricitabine backbone

Introduction Pre‐ and post‐exposure prophylaxis (PrEP and PEP) are important pillars of the HIV prevention portfolio to reduce the risk of acquisition just before or after HIV exposure. While PrEP efficacy has been elucidated in many randomized clinical trials, corresponding data for PEP is extremel...

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Bibliographic Details
Published in:	Journal of the International AIDS Society Vol. 28; no. S1; pp. e26454 - n/a
Main Authors:	Zhang, Lanxin, Collins, Simon, Fox, Julie, Kleist, Max
Format:	Journal Article
Language:	English
Published:	Switzerland John Wiley & Sons, Inc 01.06.2025 John Wiley and Sons Inc Wiley
Subjects:	Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Antiretroviral drugs Binomial distribution Chemoprevention - methods Clinical trials Disease prevention Drug dosages Emtricitabine - administration & dosage Emtricitabine - pharmacokinetics Emtricitabine - therapeutic use Exposure Health risks HIV HIV Infections - prevention & control Human immunodeficiency virus Humans Infections Male mathematical modelling Mathematical models Ordinary differential equations Pharmacokinetics Post-Exposure Prophylaxis - methods post‐exposure prophylaxis Pre-Exposure Prophylaxis - methods pre‐exposure prophylaxis Probability Prophylaxis quantitative systems pharmacology Risk reduction TDF/FTC Tenofovir - administration & dosage Tenofovir - pharmacokinetics Time Factors Treatment Outcome Vagina Viruses pre‐exposure prophylaxis TDF/FTC mathematical modelling HIV post‐exposure prophylaxis quantitative systems pharmacology
ISSN:	1758-2652, 1758-2652
Online Access:	Get full text
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