Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy

For patients diagnosed with advanced renal cell carcinoma (RCC), there are few therapeutic options. Radiation therapy is predominantly used to treat metastasis and has not proven effective in the adjuvant setting for renal cancer. Furthermore, RCC is resistant to standard cytotoxic chemotherapies. T...

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Bibliographic Details
Published in:	Radiotherapy and oncology Vol. 103; no. 3; pp. 388 - 393
Main Authors:	Anbalagan, Selvakumar, Pires, Isabel M., Blick, Christopher, Hill, Mark A., Ferguson, David J.P., Chan, Denise A., Hammond, Ester M.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.06.2012
Subjects:	Antineoplastic Agents - pharmacology Autophagy Autophagy - drug effects Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - physiopathology Carcinoma, Renal Cell - radiotherapy Cell Cycle - drug effects Cell Cycle - radiation effects Cell Hypoxia Cell Line, Tumor Cell Survival - drug effects Cell Survival - radiation effects Hematology, Oncology and Palliative Medicine Humans Hypoxia Kidney Neoplasms - genetics Kidney Neoplasms - physiopathology Kidney Neoplasms - radiotherapy Mutation Pyridines - pharmacology Radiation Radiation Dosage Radiation Tolerance - physiology Radiosensitivity Sirolimus - analogs & derivatives Sirolimus - pharmacology Thiazoles - pharmacology Tumor Stem Cell Assay VHL Von Hippel-Lindau Tumor Suppressor Protein - genetics Hypoxia Radiosensitivity VHL Autophagy Radiation
ISSN:	0167-8140, 1879-0887, 1879-0887
Online Access:	Get full text
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