The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

Accurate DNA replication and DNA repair are crucial for the maintenance of genome stability, and it is generally accepted that failure of these processes is a major source of DNA damage in cells. Intriguingly, recent evidence suggests that DNA damage is more likely to occur at genomic loci with high...

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Bibliographic Details
Published in:	DNA repair Vol. 19; pp. 84 - 94
Main Authors:	Hamperl, Stephan, Cimprich, Karlene A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2014
Subjects:	Activation-induced deaminase (AID) APOBEC family ASF splicing factor DNA - chemistry DNA - genetics DNA Breaks, Double-Stranded DNA Damage - genetics DNA Replication - genetics Double-strand breaks G-quadruplex Genome instability Genomic Instability - genetics Humans mRNP biogenesis Nucleic Acid Conformation R-loops RNA - chemistry RNA - genetics RNA processing factors RNA:DNA helicases RNase H Saccharomyces cerevisiae Senataxin THO/TREX complex THSC/TREX-2 Topoisomerase Transcription, Genetic Transcription–replication conflicts Senataxin TAM TAR THO/TREX complex ChIP SSB(s) THSC/TREX-2 Double-strand breaks CFS Transcription–replication conflicts RNP APOBEC AID mRNP biogenesis ssDNA Activation-induced deaminase (AID) RNAP(s) CSR G-quadruplex Genome instability CIN ASF splicing factor APOBEC family rDNA DSB(s) CTD RNA processing factors Topoisomerase RNase H R-loops RNA:DNA helicases
ISSN:	1568-7864, 1568-7856, 1568-7856
Online Access:	Get full text
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