Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

Bacteremia (bacterial bloodstream infection) is a major cause of illness and death in sub-Saharan Africa but little is known about the role of human genetics in susceptibility. We conducted a genome-wide association study of bacteremia susceptibility in more than 5,000 Kenyan children as part of the...

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Vydané v:	American journal of human genetics Ročník 98; číslo 6; s. 1092
Hlavní autori:	Rautanen, Anna, Pirinen, Matti, Mills, Tara C, Rockett, Kirk A, Strange, Amy, Ndungu, Anne W, Naranbhai, Vivek, Gilchrist, James J, Bellenguez, Céline, Freeman, Colin, Band, Gavin, Bumpstead, Suzannah J, Edkins, Sarah, Giannoulatou, Eleni, Gray, Emma, Dronov, Serge, Hunt, Sarah E, Langford, Cordelia, Pearson, Richard D, Su, Zhan, Vukcevic, Damjan, Macharia, Alex W, Uyoga, Sophie, Ndila, Carolyne, Mturi, Neema, Njuguna, Patricia, Mohammed, Shebe, Berkley, James A, Mwangi, Isaiah, Mwarumba, Salim, Kitsao, Barnes S, Lowe, Brett S, Morpeth, Susan C, Khandwalla, Iqbal, Blackwell, Jenefer M, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S, Mathew, Christopher G, Palmer, Colin N A, Plomin, Robert, Sawcer, Stephen J, Trembath, Richard C, Viswanathan, Ananth C, Wood, Nicholas W, Deloukas, Panos, Peltonen, Leena, Williams, Thomas N, Scott, J Anthony G, Chapman, Stephen J, Donnelly, Peter, Hill, Adrian V S, Spencer, Chris C A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 02.06.2016
Predmet:	Adolescent Bacteremia - genetics Bacteremia - microbiology Bacteremia - pathology Case-Control Studies Child Child, Preschool Genome-Wide Association Study Humans Infant Infant, Newborn Kenya - epidemiology Pneumonia, Pneumococcal - genetics Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - pathology Polymorphism, Genetic - genetics Risk Factors RNA, Long Noncoding - genetics Streptococcus pneumoniae - genetics
ISSN:	1537-6605, 1537-6605
On-line prístup:	Zistit podrobnosti o prístupe
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