Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

Recent experimental models and epidemiological studies suggest that specific environmental contaminants (ECs) contribute to the initiation and pathology of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms linking EC exposure with NAFLD remain poorly understood and there...

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Veröffentlicht in:	Journal of hepatology Jg. 76; H. 2; S. 283 - 293
Hauptverfasser:	Sen, Partho, Qadri, Sami, Luukkonen, Panu K., Ragnarsdottir, Oddny, McGlinchey, Aidan, Jäntti, Sirkku, Juuti, Anne, Arola, Johanna, Schlezinger, Jennifer J., Webster, Thomas F., Orešič, Matej, Yki-Järvinen, Hannele, Hyötyläinen, Tuulia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.02.2022 Elsevier Science Ltd
Schlagworte:	Adult Amino Acids - analysis Amino Acids - blood Animal models Animals Bile bile acid Bile acids Biopsy chemical exposure Cohort Studies Contaminants Disease Models, Animal Environmental Exposure - adverse effects Environmental Exposure - statistics & numerical data Epidemiology exposome Fatty Acids, Nonesterified - analysis Fatty Acids, Nonesterified - blood Fatty liver Female Females fibrosis Glucose metabolism Humans Lipid metabolism Lipid Metabolism - immunology Lipid Metabolism - physiology lipidome Lipids Liver diseases Male Mass spectroscopy metabolic pathway Metabolic pathways Metabolism metabolome Mice Middle Aged non- alcoholic steatohepatitis Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - metabolism perfluorinated alkyl substance Sex differences metabolic pathway exposome bile acid perfluorinated alkyl substance fibrosis lipidome chemical exposure metabolome non-alcoholic steatohepatitis
ISSN:	0168-8278, 1600-0641, 1600-0641
Online-Zugang:	Volltext
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