Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability

Aurora kinases are key regulators of chromosome segregation during mitosis. We have previously shown by microarray analysis of primary lung carcinomas and matched normal tissue that AURKB (22 out of 37) and AURKA (15 out of 37) transcripts are frequently over-represented in these tumours. We now con...

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Vydáno v:	British journal of cancer Ročník 93; číslo 6; s. 719 - 729
Hlavní autoři:	Smith, S L, Bowers, N L, Betticher, D C, Gautschi, O, Ratschiller, D, Hoban, P R, Booton, R, Santibáñez-Koref, M F, Heighway, J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 19.09.2005 Nature Publishing Group
Témata:	Allelic Imbalance Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Aurora Kinase A Aurora Kinase B Aurora Kinases Biological and medical sciences Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Catalytic Domain DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance Epidemiology Epithelial Cells - metabolism Epithelial Cells - pathology Gene expression Gene Expression Regulation, Enzymologic Genes, Tumor Suppressor Genetics and Genomics Genomics Humans Kinases Lung cancer Lung Neoplasms - enzymology Lung Neoplasms - pathology Medical research Medical sciences Microsatellite Repeats Molecular Medicine Oncology Pneumology Polymorphism, Restriction Fragment Length Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction Serine Proteinase Inhibitors - genetics Serine Proteinase Inhibitors - metabolism Serpins - genetics Serpins - metabolism Telomerase - genetics Telomerase - metabolism Tumors Tumors of the respiratory system and mediastinum Up-Regulation United Kingdom > UK lung cancer genetic instability stem cells aurora Lung disease Respiratory disease Lung cancer Stem cell Gene overexpression Malignant tumor non-small cell lung carcinoma Genetic instability Allele Cancerology Aurora B kinase Primary Bronchus disease Frequency Genetics
ISSN:	0007-0920, 1532-1827
On-line přístup:	Získat plný text
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