Epidemiology of Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000 incident esophageal cancers each year. Regions of high incidence include Eastern to Central Asia, along the Rift Valley in East Africa, and into South Africa. There are many causes of ESCC, which vary among regions. Earl...

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Vydáno v:Gastroenterology (New York, N.Y. 1943) Ročník 154; číslo 2; s. 360
Hlavní autoři: Abnet, Christian C, Arnold, Melina, Wei, Wen-Qiang
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.01.2018
Témata:
Adenocarcinoma - epidemiology
Adenocarcinoma - etiology
Alcohol Drinking - adverse effects
Body Mass Index
Carcinogens - toxicity
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - microbiology
Esophageal Neoplasms - epidemiology
Esophageal Neoplasms - etiology
Esophageal Neoplasms - microbiology
Esophageal Squamous Cell Carcinoma
Female
Gastrointestinal Microbiome
Genetic Predisposition to Disease - genetics
Hot Temperature - adverse effects
Humans
Incidence
Male
Micronutrients
Oral Health
Papillomaviridae - isolation & purification
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Polycyclic Aromatic Hydrocarbons - toxicity
Polymorphism, Single Nucleotide - genetics
Risk Factors
Sex Factors
Smoking - adverse effects
Social Class
Esophageal Cancer
Squamous Cell Carcinoma
Epidemiology
Genetic Epidemiology
ISSN:1528-0012, 1528-0012
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Shrnutí:Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000 incident esophageal cancers each year. Regions of high incidence include Eastern to Central Asia, along the Rift Valley in East Africa, and into South Africa. There are many causes of ESCC, which vary among regions. Early studies in France associated smoking cigarettes and heavy alcohol consumption with high rates of ESCC, but these factors cannot explain the high incidence in other regions. We discuss other risk factors for ESCC, including polycyclic aromatic hydrocarbons from a variety of sources, high-temperature foods, diet, and oral health and the microbiome-all require further research. A growing list of defined genomic regions affects susceptibility, but large genome-wide association studies have been conducted with ethnic Chinese subjects only; more studies are called for in the rest of Asia and Africa. ESCC has been understudied, but growing infrastructure in more high-incidence countries will allow rapid progress in our understanding.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1528-0012
1528-0012
DOI:10.1053/j.gastro.2017.08.023