Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

•Structure-function coupling of interictal epileptic discharges (IEDs) was studied with graph signal processing for the first time.•The predominance of smooth vs coarse spatial maps changes during the IED and points at stronger integration mechanisms during IEDs.•This effect was localized in the ips...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clinical neurophysiology Ročník 153; s. 1 - 10
Hlavní autoři: Rigoni, I., Rué Queralt, J., Glomb, K., Preti, M.G., Roehri, N., Tourbier, S., Spinelli, L., Seeck, M., Van De Ville, D., Hagmann, P., Vulliémoz, S.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.09.2023
Témata:
EEG
Graph signal processing
Neurology
Structure–function coupling
Temporal lobe epilepsy
GSP
EEG
Temporal lobe epilepsy
IED
Structure–function coupling
TLE
Graph signal processing
temporal lobe epilepsy
structure-function coupling
graph signal processing
ISSN:1388-2457, 1872-8952, 1872-8952
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:•Structure-function coupling of interictal epileptic discharges (IEDs) was studied with graph signal processing for the first time.•The predominance of smooth vs coarse spatial maps changes during the IED and points at stronger integration mechanisms during IEDs.•This effect was localized in the ipsilateral mesial temporal regions of patients with temporal lobe epilepsy. Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE). We decomposed IEDs of 17 patients on spatial maps, i.e. network harmonics, extracted from a structural connectome. Harmonics were split in smooth maps (long-range interactions reflecting integration) and coarse maps (short-range interactions reflecting segregation) and were used to reconstruct the part of the signal coupled (Xc) and decoupled (Xd) from the structure, respectively. We analysed how Xc and Xd embed the IED energy over time, at global and regional level. For Xc, the energy was smaller than for Xd before the IED onset (p < .001), but became larger around the first IED peak (p < .05, cluster 2, C2). Locally, the ipsilateral mesial regions were significantly coupled to the structure over the whole epoch. The ipsilateral hippocampus increased its coupling during C2 (p < .01). At whole-brain level, segregation gives way to integrative processes during the IED. Locally, brain regions commonly involved in the TLE epileptogenic network increase their reliance on long-range couplings during IED (C2). In TLE, integration mechanisms prevail during the IED and are localized in the ipsilateral mesial temporal regions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1388-2457
1872-8952
1872-8952
DOI:10.1016/j.clinph.2023.05.012